Dekker FJ - Search Results

1

Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases.

Dekker FJ, van den Bosch T, Martin NI. Dekker FJ, et al. Drug Discov Today. 2014 May;19(5):654-60. doi: 10.1016/j.drudis.2013.11.012. Epub 2013 Nov 21. Drug Discov Today. 2014. PMID: 24269836 Free article. Review.

2

Inhibition of the PCAF histone acetyl transferase and cell proliferation by isothiazolones.

Dekker FJ, Ghizzoni M, van der Meer N, Wisastra R, Haisma HJ. Dekker FJ, et al. Bioorg Med Chem. 2009 Jan 15;17(2):460-6. doi: 10.1016/j.bmc.2008.12.008. Epub 2008 Dec 13. Bioorg Med Chem. 2009. PMID: 19111471

3

Histone acetyl transferases as emerging drug targets.

Dekker FJ, Haisma HJ. Dekker FJ, et al. Drug Discov Today. 2009 Oct;14(19-20):942-8. doi: 10.1016/j.drudis.2009.06.008. Epub 2009 Jul 2. Drug Discov Today. 2009. PMID: 19577000 Review.

4

Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative.

Ghizzoni M, Boltjes A, Graaf Cd, Haisma HJ, Dekker FJ. Ghizzoni M, et al. Among authors: dekker fj. Bioorg Med Chem. 2010 Aug 15;18(16):5826-34. doi: 10.1016/j.bmc.2010.06.089. Epub 2010 Jul 3. Bioorg Med Chem. 2010. PMID: 20655754

5

Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation.

Ghizzoni M, Haisma HJ, Maarsingh H, Dekker FJ. Ghizzoni M, et al. Among authors: dekker fj. Drug Discov Today. 2011 Jun;16(11-12):504-11. doi: 10.1016/j.drudis.2011.03.009. Epub 2011 Apr 6. Drug Discov Today. 2011. PMID: 21477662 Free PMC article. Review.

6

6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site.

Ghizzoni M, Wu J, Gao T, Haisma HJ, Dekker FJ, George Zheng Y. Ghizzoni M, et al. Among authors: dekker fj. Eur J Med Chem. 2012 Jan;47(1):337-44. doi: 10.1016/j.ejmech.2011.11.001. Epub 2011 Nov 10. Eur J Med Chem. 2012. PMID: 22100137 Free PMC article.

7

Delivery of epidrugs.

el Bahhaj F, Dekker FJ, Martinet N, Bertrand P. el Bahhaj F, et al. Among authors: dekker fj. Drug Discov Today. 2014 Sep;19(9):1337-52. doi: 10.1016/j.drudis.2014.03.017. Epub 2014 Mar 25. Drug Discov Today. 2014. PMID: 24680930 Review.

8

Light-Controlled Histone Deacetylase (HDAC) Inhibitors: Towards Photopharmacological Chemotherapy.

Szymanski W, Ourailidou ME, Velema WA, Dekker FJ, Feringa BL. Szymanski W, et al. Among authors: dekker fj. Chemistry. 2015 Nov 9;21(46):16517-16524. doi: 10.1002/chem.201502809. Epub 2015 Sep 29. Chemistry. 2015. PMID: 26418117 Free PMC article.

9

Enzyme kinetics and inhibition of histone acetyltransferase KAT8.

Wapenaar H, van der Wouden PE, Groves MR, Rotili D, Mai A, Dekker FJ. Wapenaar H, et al. Among authors: dekker fj. Eur J Med Chem. 2015 Nov 13;105:289-96. doi: 10.1016/j.ejmech.2015.10.016. Epub 2015 Oct 22. Eur J Med Chem. 2015. PMID: 26505788 Free PMC article.

10

The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases.

van den Bosch T, Boichenko A, Leus NGJ, Ourailidou ME, Wapenaar H, Rotili D, Mai A, Imhof A, Bischoff R, Haisma HJ, Dekker FJ. van den Bosch T, et al. Among authors: dekker fj. Biochem Pharmacol. 2016 Feb 15;102:130-140. doi: 10.1016/j.bcp.2015.12.010. Epub 2015 Dec 21. Biochem Pharmacol. 2016. PMID: 26718586 Free PMC article.

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