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Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation.
Muendlein HI, Sarhan J, Liu BC, Connolly WM, Schworer SA, Smirnova I, Tang AY, Ilyukha V, Pietruska J, Tahmasebi S, Sonenberg N, Degterev A, Poltorak A. Muendlein HI, et al. Among authors: degterev a. Cell Rep. 2020 Jan 21;30(3):699-713.e4. doi: 10.1016/j.celrep.2019.12.073. Cell Rep. 2020. PMID: 31968247 Free PMC article.
RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4.
Najjar M, Saleh D, Zelic M, Nogusa S, Shah S, Tai A, Finger JN, Polykratis A, Gough PJ, Bertin J, Whalen M, Pasparakis M, Balachandran S, Kelliher M, Poltorak A, Degterev A. Najjar M, et al. Among authors: degterev a. Immunity. 2016 Jul 19;45(1):46-59. doi: 10.1016/j.immuni.2016.06.007. Epub 2016 Jul 5. Immunity. 2016. PMID: 27396959 Free PMC article.
Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide.
Saleh D, Najjar M, Zelic M, Shah S, Nogusa S, Polykratis A, Paczosa MK, Gough PJ, Bertin J, Whalen M, Fitzgerald KA, Slavov N, Pasparakis M, Balachandran S, Kelliher M, Mecsas J, Degterev A. Saleh D, et al. Among authors: degterev a. J Immunol. 2017 Jun 1;198(11):4435-4447. doi: 10.4049/jimmunol.1601717. Epub 2017 May 1. J Immunol. 2017. PMID: 28461567 Free PMC article.
Targeting RIPK1 for the treatment of human diseases.
Degterev A, Ofengeim D, Yuan J. Degterev A, et al. Proc Natl Acad Sci U S A. 2019 May 14;116(20):9714-9722. doi: 10.1073/pnas.1901179116. Epub 2019 May 2. Proc Natl Acad Sci U S A. 2019. PMID: 31048504 Free PMC article. Review.
97 results