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DNA Modifications Enabling Proximity Biotinylation.
Wilbanks B, Pearson K, Byrne SR, Bickart LB, Dedon PC, Maher LJ 3rd. Wilbanks B, et al. Among authors: dedon pc. Bioconjug Chem. 2023 Mar 8;34(4):611-5. doi: 10.1021/acs.bioconjchem.2c00475. Online ahead of print. Bioconjug Chem. 2023. PMID: 36888923 Free PMC article.
Strategies to Avoid Artifacts in Mass Spectrometry-Based Epitranscriptome Analyses.
Kaiser S, Byrne SR, Ammann G, Asadi Atoi P, Borland K, Brecheisen R, DeMott MS, Gehrke T, Hagelskamp F, Heiss M, Yoluç Y, Liu L, Zhang Q, Dedon PC, Cao B, Kellner S. Kaiser S, et al. Among authors: dedon pc. Angew Chem Int Ed Engl. 2021 Oct 25;60(44):23885-23893. doi: 10.1002/anie.202106215. Epub 2021 Sep 29. Angew Chem Int Ed Engl. 2021. PMID: 34339593 Free PMC article.
The absence of the queuosine tRNA modification leads to pleiotropic phenotypes revealing perturbations of metal and oxidative stress homeostasis in Escherichia coli K12.
Pollo-Oliveira L, Davis NK, Hossain I, Ho P, Yuan Y, Salguero García P, Pereira C, Byrne SR, Leng J, Sze M, Blaby-Haas CE, Sekowska A, Montoya A, Begley T, Danchin A, Aalberts DP, Angerhofer A, Hunt J, Conesa A, Dedon PC, de Crécy-Lagard V. Pollo-Oliveira L, et al. Among authors: dedon pc. Metallomics. 2022 Sep 24;14(9):mfac065. doi: 10.1093/mtomcs/mfac065. Metallomics. 2022. PMID: 36066904 Free PMC article.
Translational response to mitochondrial stresses is orchestrated by tRNA modifications.
Rashad S, Al-Mesitef S, Mousa A, Zhou Y, Ando D, Sun G, Fukuuchi T, Iwasaki Y, Xiang J, Byrne SR, Sun J, Maekawa M, Saigusa D, Begley TJ, Dedon PC, Niizuma K. Rashad S, et al. Among authors: dedon pc. bioRxiv [Preprint]. 2024 Feb 14:2024.02.14.580389. doi: 10.1101/2024.02.14.580389. bioRxiv. 2024. PMID: 38405984 Free PMC article. Preprint.
Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
Zhong W, Pasunooti KK, Balamkundu S, Wong YH, Nah Q, Gadi V, Gnanakalai S, Chionh YH, McBee ME, Gopal P, Lim SH, Olivier N, Buurman ET, Dick T, Liu CF, Lescar J, Dedon PC. Zhong W, et al. Among authors: dedon pc. J Med Chem. 2019 Sep 12;62(17):7788-7805. doi: 10.1021/acs.jmedchem.9b00582. Epub 2019 Aug 29. J Med Chem. 2019. PMID: 31442049 Free PMC article.
7-Deazaguanine modifications protect phage DNA from host restriction systems.
Hutinet G, Kot W, Cui L, Hillebrand R, Balamkundu S, Gnanakalai S, Neelakandan R, Carstens AB, Fa Lui C, Tremblay D, Jacobs-Sera D, Sassanfar M, Lee YJ, Weigele P, Moineau S, Hatfull GF, Dedon PC, Hansen LH, de Crécy-Lagard V. Hutinet G, et al. Among authors: dedon pc. Nat Commun. 2019 Nov 29;10(1):5442. doi: 10.1038/s41467-019-13384-y. Nat Commun. 2019. PMID: 31784519 Free PMC article.
229 results