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A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling.
Schreiber JA, Möller M, Zaydman M, Zhao L, Beller Z, Becker S, Ritter N, Hou P, Shi J, Silva J, Wrobel E, Strutz-Seebohm N, Decher N, Schmitt N, Meuth SG, Düfer M, Wünsch B, Cui J, Seebohm G. Schreiber JA, et al. Among authors: decher n. Commun Biol. 2022 Apr 1;5(1):301. doi: 10.1038/s42003-022-03229-8. Commun Biol. 2022. PMID: 35365746 Free PMC article.
Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability.
Arévalo B, Bedoya M, Kiper AK, Vergara F, Ramírez D, Mazola Y, Bustos D, Zúñiga R, Cikutovic R, Cayo A, Rinné S, Ramirez-Apan MT, Sepúlveda FV, Cerda O, López-Collazo E, Decher N, Zúñiga L, Gutierrez M, González W. Arévalo B, et al. Among authors: decher n. J Med Chem. 2022 Nov 24;65(22):15014-15027. doi: 10.1021/acs.jmedchem.1c00378. Epub 2022 Nov 15. J Med Chem. 2022. PMID: 36378530
Altered stress stimulation of inward rectifier potassium channels in Andersen-Tawil syndrome.
Seebohm G, Strutz-Seebohm N, Ursu ON, Preisig-Müller R, Zuzarte M, Hill EV, Kienitz MC, Bendahhou S, Fauler M, Tapken D, Decher N, Collins A, Jurkat-Rott K, Steinmeyer K, Lehmann-Horn F, Daut J, Tavaré JM, Pott L, Bloch W, Lang F. Seebohm G, et al. Among authors: decher n. FASEB J. 2012 Feb;26(2):513-22. doi: 10.1096/fj.11-189126. Epub 2011 Oct 14. FASEB J. 2012. PMID: 22002906
Side pockets provide the basis for a new mechanism of Kv channel-specific inhibition.
Marzian S, Stansfeld PJ, Rapedius M, Rinné S, Nematian-Ardestani E, Abbruzzese JL, Steinmeyer K, Sansom MS, Sanguinetti MC, Baukrowitz T, Decher N. Marzian S, et al. Among authors: decher n. Nat Chem Biol. 2013 Aug;9(8):507-13. doi: 10.1038/nchembio.1271. Epub 2013 Jun 2. Nat Chem Biol. 2013. PMID: 23728494 Free PMC article.
105 results