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Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells.
Schumann B, Malaker SA, Wisnovsky SP, Debets MF, Agbay AJ, Fernandez D, Wagner LJS, Lin L, Li Z, Choi J, Fox DM, Peh J, Gray MA, Pedram K, Kohler JJ, Mrksich M, Bertozzi CR. Schumann B, et al. Among authors: debets mf. Mol Cell. 2020 Jun 4;78(5):824-834.e15. doi: 10.1016/j.molcel.2020.03.030. Epub 2020 Apr 22. Mol Cell. 2020. PMID: 32325029 Free PMC article.
Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs.
Choi J, Wagner LJS, Timmermans SBPE, Malaker SA, Schumann B, Gray MA, Debets MF, Takashima M, Gehring J, Bertozzi CR. Choi J, et al. Among authors: debets mf. J Am Chem Soc. 2019 Aug 28;141(34):13442-13453. doi: 10.1021/jacs.9b04695. Epub 2019 Aug 16. J Am Chem Soc. 2019. PMID: 31373799 Free PMC article.
Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation.
Debets MF, Tastan OY, Wisnovsky SP, Malaker SA, Angelis N, Moeckl LKR, Choi J, Flynn H, Wagner LJS, Bineva-Todd G, Antonopoulos A, Cioce A, Browne WM, Li Z, Briggs DC, Douglas HL, Hess GT, Agbay AJ, Roustan C, Kjaer S, Haslam SM, Snijders AP, Bassik MC, Moerner WE, Li VSW, Bertozzi CR, Schumann B. Debets MF, et al. Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25293-25301. doi: 10.1073/pnas.2007297117. Epub 2020 Sep 28. Proc Natl Acad Sci U S A. 2020. PMID: 32989128 Free PMC article.
Optimization of Metabolic Oligosaccharide Engineering with Ac4GalNAlk and Ac4GlcNAlk by an Engineered Pyrophosphorylase.
Cioce A, Bineva-Todd G, Agbay AJ, Choi J, Wood TM, Debets MF, Browne WM, Douglas HL, Roustan C, Tastan OY, Kjaer S, Bush JT, Bertozzi CR, Schumann B. Cioce A, et al. Among authors: debets mf. ACS Chem Biol. 2021 Oct 15;16(10):1961-1967. doi: 10.1021/acschembio.1c00034. Epub 2021 Apr 9. ACS Chem Biol. 2021. PMID: 33835779 Free PMC article.
Manno-epi-cyclophellitols Enable Activity-Based Protein Profiling of Human α-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors.
Armstrong Z, Kuo CL, Lahav D, Liu B, Johnson R, Beenakker TJM, de Boer C, Wong CS, van Rijssel ER, Debets MF, Florea BI, Hissink C, Boot RG, Geurink PP, Ovaa H, van der Stelt M, van der Marel GM, Codée JDC, Aerts JMFG, Wu L, Overkleeft HS, Davies GJ. Armstrong Z, et al. Among authors: debets mf. J Am Chem Soc. 2020 Jul 29;142(30):13021-13029. doi: 10.1021/jacs.0c03880. Epub 2020 Jul 16. J Am Chem Soc. 2020. PMID: 32605368
Quantitative Measurement of Cytosolic and Nuclear Penetration of Oligonucleotide Therapeutics.
Deprey K, Batistatou N, Debets MF, Godfrey J, VanderWall KB, Miles RR, Shehaj L, Guo J, Andreucci A, Kandasamy P, Lu G, Shimizu M, Vargeese C, Kritzer JA. Deprey K, et al. Among authors: debets mf. ACS Chem Biol. 2022 Feb 18;17(2):348-360. doi: 10.1021/acschembio.1c00830. Epub 2022 Jan 15. ACS Chem Biol. 2022. PMID: 35034446 Free PMC article.
Spiro-epoxyglycosides as Activity-Based Probes for Glycoside Hydrolase Family 99 Endomannosidase/Endomannanase.
Schröder SP, Kallemeijn WW, Debets MF, Hansen T, Sobala LF, Hakki Z, Williams SJ, Beenakker TJM, Aerts JMFG, van der Marel GA, Codée JDC, Davies GJ, Overkleeft HS. Schröder SP, et al. Among authors: debets mf. Chemistry. 2018 Jul 11;24(39):9983-9992. doi: 10.1002/chem.201801902. Epub 2018 Jun 21. Chemistry. 2018. PMID: 29797675 Free PMC article.
Detection of transglutaminase activity using click chemistry.
van Geel R, Debets MF, Löwik DW, Pruijn GJ, Boelens WC. van Geel R, et al. Among authors: debets mf. Amino Acids. 2012 Sep;43(3):1251-63. doi: 10.1007/s00726-011-1198-2. Epub 2011 Dec 17. Amino Acids. 2012. PMID: 22180026 Free PMC article.
21 results