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Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura.
Scully M, Cataland SR, Peyvandi F, Coppo P, Knöbl P, Kremer Hovinga JA, Metjian A, de la Rubia J, Pavenski K, Callewaert F, Biswas D, De Winter H, Zeldin RK; HERCULES Investigators. Scully M, et al. Among authors: de winter h, de la rubia j. N Engl J Med. 2019 Jan 24;380(4):335-346. doi: 10.1056/NEJMoa1806311. Epub 2019 Jan 9. N Engl J Med. 2019. PMID: 30625070 Free article. Clinical Trial.
Efficacy and safety of open-label caplacizumab in patients with exacerbations of acquired thrombotic thrombocytopenic purpura in the HERCULES study.
Knoebl P, Cataland S, Peyvandi F, Coppo P, Scully M, Kremer Hovinga JA, Metjian A, de la Rubia J, Pavenski K, Minkue Mi Edou J, De Winter H, Callewaert F. Knoebl P, et al. Among authors: de winter h, de la rubia j. J Thromb Haemost. 2020 Feb;18(2):479-484. doi: 10.1111/jth.14679. Epub 2019 Dec 9. J Thromb Haemost. 2020. PMID: 31691462 Free PMC article. Clinical Trial.
Caplacizumab reduces the frequency of major thromboembolic events, exacerbations and death in patients with acquired thrombotic thrombocytopenic purpura.
Peyvandi F, Scully M, Kremer Hovinga JA, Knöbl P, Cataland S, De Beuf K, Callewaert F, De Winter H, Zeldin RK. Peyvandi F, et al. Among authors: de winter h, de beuf k. J Thromb Haemost. 2017 Jul;15(7):1448-1452. doi: 10.1111/jth.13716. Epub 2017 Jun 5. J Thromb Haemost. 2017. PMID: 28445600 Free article. Clinical Trial.
Molecule auto-correction to facilitate molecular design.
Kerstjens A, De Winter H. Kerstjens A, et al. Among authors: de winter h. J Comput Aided Mol Des. 2024 Feb 16;38(1):10. doi: 10.1007/s10822-024-00549-1. J Comput Aided Mol Des. 2024. PMID: 38363377 Free PMC article.
Highly Selective Inhibitors of Dipeptidyl Peptidase 9 (DPP9) Derived from the Clinically Used DPP4-Inhibitor Vildagliptin.
Benramdane S, De Loose J, Filippi N, Espadinha M, Beyens O, Rymenant YV, Dirkx L, Bozdag M, Feijens PB, Augustyns K, Caljon G, De Winter H, De Meester I, Van der Veken P. Benramdane S, et al. Among authors: de winter h. J Med Chem. 2023 Sep 28;66(18):12717-12738. doi: 10.1021/acs.jmedchem.3c00609. Epub 2023 Sep 18. J Med Chem. 2023. PMID: 37721854
65 results