De Strooper B - Search Results

1

The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.

Sala Frigerio C, Wolfs L, Fattorelli N, Thrupp N, Voytyuk I, Schmidt I, Mancuso R, Chen WT, Woodbury ME, Srivastava G, Möller T, Hudry E, Das S, Saido T, Karran E, Hyman B, Perry VH, Fiers M, De Strooper B. Sala Frigerio C, et al. Among authors: de strooper b. Cell Rep. 2019 Apr 23;27(4):1293-1306.e6. doi: 10.1016/j.celrep.2019.03.099. Cell Rep. 2019. PMID: 31018141 Free PMC article.

2

alpha 2-Macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease.

Van Gool D, De Strooper B, Van Leuven F, Triau E, Dom R. Van Gool D, et al. Among authors: de strooper b. Neurobiol Aging. 1993 May-Jun;14(3):233-7. doi: 10.1016/0197-4580(93)90006-w. Neurobiol Aging. 1993. PMID: 7686641

3

Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease.

De Strooper B. De Strooper B. EMBO Rep. 2007 Feb;8(2):141-6. doi: 10.1038/sj.embor.7400897. EMBO Rep. 2007. PMID: 17268505 Free PMC article. Review.

4

gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.

Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, Yang Z, May PC, Karran E, Wiltfang J, D'Hooge R, De Strooper B. Serneels L, et al. Among authors: de strooper b. Science. 2009 May 1;324(5927):639-42. doi: 10.1126/science.1171176. Epub 2009 Mar 19. Science. 2009. PMID: 19299585 Free PMC article.

5

Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio.

Uemura K, Lill CM, Li X, Peters JA, Ivanov A, Fan Z, DeStrooper B, Bacskai BJ, Hyman BT, Berezovska O. Uemura K, et al. PLoS One. 2009 Nov 18;4(11):e7893. doi: 10.1371/journal.pone.0007893. PLoS One. 2009. PMID: 19924286 Free PMC article.

6

Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1.

Zhou L, Chávez-Gutiérrez L, Bockstael K, Sannerud R, Annaert W, May PC, Karran E, De Strooper B. Zhou L, et al. Among authors: de strooper b. J Biol Chem. 2011 Mar 11;286(10):8677-8687. doi: 10.1074/jbc.M110.194860. Epub 2011 Jan 5. J Biol Chem. 2011. PMID: 21209097 Free PMC article.

7

An overlooked neurotoxic species in Alzheimer's disease.

Benilova I, De Strooper B. Benilova I, et al. Among authors: de strooper b. Nat Neurosci. 2011 Jul 26;14(8):949-50. doi: 10.1038/nn.2871. Nat Neurosci. 2011. PMID: 21792191 No abstract available.

8

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics.

Karran E, Mercken M, De Strooper B. Karran E, et al. Among authors: de strooper b. Nat Rev Drug Discov. 2011 Aug 19;10(9):698-712. doi: 10.1038/nrd3505. Nat Rev Drug Discov. 2011. PMID: 21852788 Review.

9

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes.

Benilova I, Karran E, De Strooper B. Benilova I, et al. Among authors: de strooper b. Nat Neurosci. 2012 Jan 29;15(3):349-57. doi: 10.1038/nn.3028. Nat Neurosci. 2012. PMID: 22286176 Review.

10

Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.

De Strooper B, Iwatsubo T, Wolfe MS. De Strooper B, et al. Cold Spring Harb Perspect Med. 2012 Jan;2(1):a006304. doi: 10.1101/cshperspect.a006304. Cold Spring Harb Perspect Med. 2012. PMID: 22315713 Free PMC article. Review.

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