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LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism.
Arranz AM, Delbroek L, Van Kolen K, Guimarães MR, Mandemakers W, Daneels G, Matta S, Calafate S, Shaban H, Baatsen P, De Bock PJ, Gevaert K, Vanden Berghe P, Verstreken P, De Strooper B, Moechars D. Arranz AM, et al. Among authors: de bock pj, de strooper b. J Cell Sci. 2015 Feb 1;128(3):541–52. doi: 10.1242/jcs.158196. J Cell Sci. 2015. PMID: 25501810
Parkin interacts with Ambra1 to induce mitophagy.
Van Humbeeck C, Cornelissen T, Hofkens H, Mandemakers W, Gevaert K, De Strooper B, Vandenberghe W. Van Humbeeck C, et al. Among authors: de strooper b. J Neurosci. 2011 Jul 13;31(28):10249-61. doi: 10.1523/JNEUROSCI.1917-11.2011. J Neurosci. 2011. PMID: 21753002 Free PMC article.
Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency.
Vos M, Esposito G, Edirisinghe JN, Vilain S, Haddad DM, Slabbaert JR, Van Meensel S, Schaap O, De Strooper B, Meganathan R, Morais VA, Verstreken P. Vos M, et al. Among authors: de strooper b. Science. 2012 Jun 8;336(6086):1306-10. doi: 10.1126/science.1218632. Epub 2012 May 10. Science. 2012. PMID: 22582012 Free article.
The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo.
Zhou L, Barão S, Laga M, Bockstael K, Borgers M, Gijsen H, Annaert W, Moechars D, Mercken M, Gevaert K, De Strooper B. Zhou L, et al. Among authors: de strooper b. J Biol Chem. 2012 Jul 27;287(31):25927-40. doi: 10.1074/jbc.M112.377465. Epub 2012 Jun 12. J Biol Chem. 2012. PMID: 22692213 Free PMC article.
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis.
Matta S, Van Kolen K, da Cunha R, van den Bogaart G, Mandemakers W, Miskiewicz K, De Bock PJ, Morais VA, Vilain S, Haddad D, Delbroek L, Swerts J, Chávez-Gutiérrez L, Esposito G, Daneels G, Karran E, Holt M, Gevaert K, Moechars DW, De Strooper B, Verstreken P. Matta S, et al. Among authors: de bock pj, de strooper b. Neuron. 2012 Sep 20;75(6):1008-21. doi: 10.1016/j.neuron.2012.08.022. Neuron. 2012. PMID: 22998870 Free article.
Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation.
Delbroek L, Van Kolen K, Steegmans L, da Cunha R, Mandemakers W, Daneels G, De Bock PJ, Zhang J, Gevaert K, De Strooper B, Alessi DR, Verstreken P, Moechars DW. Delbroek L, et al. Among authors: de bock pj, de strooper b. J Pharm Biomed Anal. 2013 Mar 25;76:49-58. doi: 10.1016/j.jpba.2012.12.002. Epub 2012 Dec 16. J Pharm Biomed Anal. 2013. PMID: 23313773 Free PMC article.
Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy.
Haddad DM, Vilain S, Vos M, Esposito G, Matta S, Kalscheuer VM, Craessaerts K, Leyssen M, Nascimento RM, Vianna-Morgante AM, De Strooper B, Van Esch H, Morais VA, Verstreken P. Haddad DM, et al. Among authors: de strooper b. Mol Cell. 2013 Jun 27;50(6):831-43. doi: 10.1016/j.molcel.2013.04.012. Epub 2013 May 16. Mol Cell. 2013. PMID: 23685073 Free article.
395 results