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1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.
Imbimbo BP, Del Giudice E, Colavito D, D'Arrigo A, Dalle Carbonare M, Villetti G, Facchinetti F, Volta R, Pietrini V, Baroc MF, Serneels L, De Strooper B, Leon A. Imbimbo BP, et al. Among authors: de strooper b. J Pharmacol Exp Ther. 2007 Dec;323(3):822-30. doi: 10.1124/jpet.107.129007. Epub 2007 Sep 25. J Pharmacol Exp Ther. 2007. PMID: 17895400
No endogenous A beta production in presenilin-deficient fibroblasts.
Nyabi O, Pype S, Mercken M, Herreman A, Saftig P, Craessaerts K, Serneels L, Annaert W, De Strooper B. Nyabi O, et al. Among authors: de strooper b. Nat Cell Biol. 2002 Jul;4(7):E164; author reply E165-6. doi: 10.1038/ncb0702-e164a. Nat Cell Biol. 2002. PMID: 12105423 No abstract available.
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo.
Serneels L, Dejaegere T, Craessaerts K, Horré K, Jorissen E, Tousseyn T, Hébert S, Coolen M, Martens G, Zwijsen A, Annaert W, Hartmann D, De Strooper B. Serneels L, et al. Among authors: de strooper b. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1719-24. doi: 10.1073/pnas.0408901102. Epub 2005 Jan 21. Proc Natl Acad Sci U S A. 2005. PMID: 15665098 Free PMC article.
395 results