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Considerations on the Design of Lipid-based mRNA Vaccines Against Cancer.
Meulewaeter S, Zhang Y, Wadhwa A, Fox K, Lentacker I, Harder KW, Cullis PR, De Smedt SC, Cheng MHY, Verbeke R. Meulewaeter S, et al. Among authors: de smedt sc. J Mol Biol. 2024 Jan 15;436(2):168385. doi: 10.1016/j.jmb.2023.168385. Epub 2023 Dec 6. J Mol Biol. 2024. PMID: 38065276 Review.
Nanomedicine to aid immunogenic cell death (ICD)-based anticancer therapy.
Demuynck R, Engelen Y, Skirtach AG, De Smedt SC, Lentacker I, Krysko DV. Demuynck R, et al. Among authors: de smedt sc. Trends Cancer. 2024 Mar 28:S2405-8033(24)00052-9. doi: 10.1016/j.trecan.2024.03.003. Online ahead of print. Trends Cancer. 2024. PMID: 38553361
Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8+ T cell and iNKT cell activating mRNA vaccine.
Ertveldt T, Meulewaeter S, De Vlaeminck Y, Olarte O, Broos K, Van Calenbergh S, Bourgeois S, Deprez J, Heremans Y, Goyvaerts C, Staels W, De Smedt S, Dewitte H, Devoogdt N, Keyaerts M, Verbeke R, Barbé K, Lentacker I, Breckpot K. Ertveldt T, et al. Among authors: de smedt s. Theranostics. 2023 Oct 9;13(15):5483-5500. doi: 10.7150/thno.85106. eCollection 2023. Theranostics. 2023. PMID: 37908728 Free PMC article.
Alpha-galactosylceramide improves the potency of mRNA LNP vaccines against cancer and intracellular bacteria.
Meulewaeter S, Aernout I, Deprez J, Engelen Y, De Velder M, Franceschini L, Breckpot K, Van Calenbergh S, Asselman C, Boucher K, Impens F, De Smedt SC, Verbeke R, Lentacker I. Meulewaeter S, et al. Among authors: de smedt sc. J Control Release. 2024 May 4;370:379-391. doi: 10.1016/j.jconrel.2024.04.052. Online ahead of print. J Control Release. 2024. PMID: 38697317 Free article.
Smart hydrogels delivered by high pressure aerosolization can prevent peritoneal adhesions.
Braet H, Fransen PP, Chen Y, Van Herck S, Mariën R, Vanhoorne V, Ceelen W, Madder A, Ballet S, Hoogenboom R, De Geest B, Hoorens A, Dankers PYW, De Smedt SC, Remaut K. Braet H, et al. Among authors: de geest b, de smedt sc. J Control Release. 2023 Oct;362:138-150. doi: 10.1016/j.jconrel.2023.08.042. Epub 2023 Aug 31. J Control Release. 2023. PMID: 37619864
Selective Replacement of Cholesterol with Cationic Amphiphilic Drugs Enables the Design of Lipid Nanoparticles with Improved RNA Delivery.
Bogaert B, Debisschop A, Ehouarne T, Van Eeckhoutte HP, De Volder J, Jacobs A, Pottie E, De Rycke R, Crabbé A, Mestdagh P, Lentacker I, Brusselle GG, Stove C, Verstraelen S, Maes T, Bracke KR, De Smedt SC, Raemdonck K. Bogaert B, et al. Among authors: de smedt sc. Nano Lett. 2024 Mar 13;24(10):2961-2971. doi: 10.1021/acs.nanolett.3c03345. Epub 2024 Mar 4. Nano Lett. 2024. PMID: 38477058
Non-viral delivery of RNA for therapeutic T cell engineering.
Berdecka D, De Smedt SC, De Vos WH, Braeckmans K. Berdecka D, et al. Among authors: de smedt sc. Adv Drug Deliv Rev. 2024 May;208:115215. doi: 10.1016/j.addr.2024.115215. Epub 2024 Feb 23. Adv Drug Deliv Rev. 2024. PMID: 38401848 Review.
402 results