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Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice.
Viayna E, Coquelle N, Cieslikiewicz-Bouet M, Cisternas P, Oliva CA, Sánchez-López E, Ettcheto M, Bartolini M, De Simone A, Ricchini M, Rendina M, Pons M, Firuzi O, Pérez B, Saso L, Andrisano V, Nachon F, Brazzolotto X, García ML, Camins A, Silman I, Jean L, Inestrosa NC, Colletier JP, Renard PY, Muñoz-Torrero D. Viayna E, et al. Among authors: de simone a. J Med Chem. 2021 Jan 14;64(1):812-839. doi: 10.1021/acs.jmedchem.0c01775. Epub 2020 Dec 28. J Med Chem. 2021. PMID: 33356266
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold.
Rampa A, Mancini F, De Simone A, Falchi F, Belluti F, Di Martino RM, Gobbi S, Andrisano V, Tarozzi A, Bartolini M, Cavalli A, Bisi A. Rampa A, et al. Among authors: de simone a. Bioorg Med Chem Lett. 2015 Jul 15;25(14):2804-8. doi: 10.1016/j.bmcl.2015.05.002. Epub 2015 May 9. Bioorg Med Chem Lett. 2015. PMID: 26003339
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.
Zha X, Lamba D, Zhang L, Lou Y, Xu C, Kang D, Chen L, Xu Y, Zhang L, De Simone A, Samez S, Pesaresi A, Stojan J, Lopez MG, Egea J, Andrisano V, Bartolini M. Zha X, et al. Among authors: de simone a. J Med Chem. 2016 Jan 14;59(1):114-31. doi: 10.1021/acs.jmedchem.5b01119. Epub 2015 Dec 29. J Med Chem. 2016. PMID: 26632651 Free article.
508 results