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From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold.
Rampa A, Mancini F, De Simone A, Falchi F, Belluti F, Di Martino RM, Gobbi S, Andrisano V, Tarozzi A, Bartolini M, Cavalli A, Bisi A. Rampa A, et al. Among authors: de simone a. Bioorg Med Chem Lett. 2015 Jul 15;25(14):2804-8. doi: 10.1016/j.bmcl.2015.05.002. Epub 2015 May 9. Bioorg Med Chem Lett. 2015. PMID: 26003339
Liquid chromatographic enzymatic studies with on-line Beta-secretase immobilized enzyme reactor and 4-(4-dimethylaminophenylazo) benzoic acid/5-[(2-aminoethyl) amino] naphthalene-1-sulfonic acid peptide as fluorogenic substrate.
De Simone A, Seidl C, Santos CA, Andrisano V. De Simone A, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Mar 15;953-954:108-14. doi: 10.1016/j.jchromb.2014.01.056. Epub 2014 Feb 11. J Chromatogr B Analyt Technol Biomed Life Sci. 2014. PMID: 24590190
Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors.
Prati F, De Simone A, Bisignano P, Armirotti A, Summa M, Pizzirani D, Scarpelli R, Perez DI, Andrisano V, Perez-Castillo A, Monti B, Massenzio F, Polito L, Racchi M, Favia AD, Bottegoni G, Martinez A, Bolognesi ML, Cavalli A. Prati F, et al. Among authors: de simone a. Angew Chem Int Ed Engl. 2015 Jan 26;54(5):1578-82. doi: 10.1002/anie.201410456. Epub 2014 Dec 11. Angew Chem Int Ed Engl. 2015. PMID: 25504761 Free article.
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.
Zha X, Lamba D, Zhang L, Lou Y, Xu C, Kang D, Chen L, Xu Y, Zhang L, De Simone A, Samez S, Pesaresi A, Stojan J, Lopez MG, Egea J, Andrisano V, Bartolini M. Zha X, et al. Among authors: de simone a. J Med Chem. 2016 Jan 14;59(1):114-31. doi: 10.1021/acs.jmedchem.5b01119. Epub 2015 Dec 29. J Med Chem. 2016. PMID: 26632651 Free article.
509 results