De Santis R - Search Results

1

Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo.

Vesci L, Milazzo FM, Stasi MA, Pace S, Manera F, Tallarico C, Cini E, Petricci E, Manetti F, De Santis R, Giannini G. Vesci L, et al. Among authors: de santis r. Eur J Med Chem. 2018 Sep 5;157:368-379. doi: 10.1016/j.ejmech.2018.07.053. Epub 2018 Jul 27. Eur J Med Chem. 2018. PMID: 30099257

2

Preclinical antitumor activity of ST7612AA1: a new oral thiol-based histone deacetylase (HDAC) inhibitor.

Vesci L, Bernasconi E, Milazzo FM, De Santis R, Gaudio E, Kwee I, Rinaldi A, Pace S, Carollo V, Giannini G, Bertoni F. Vesci L, et al. Among authors: de santis r. Oncotarget. 2015 Mar 20;6(8):5735-48. doi: 10.18632/oncotarget.3240. Oncotarget. 2015. PMID: 25671299 Free PMC article.

3

Growth inhibition of human ovarian carcinoma by a novel AvidinOX-anchored biotinylated camptothecin derivative.

Minenkova O, Vesci L, De Santis R, Santapaola D, Cincinelli R, Musso L, Dallavalle S, Giannini G. Minenkova O, et al. Among authors: de santis r. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3312-3314. doi: 10.1016/j.bmcl.2018.09.017. Epub 2018 Sep 15. Bioorg Med Chem Lett. 2018. PMID: 30243588 Free article.

4

Synthesis and preliminary in vitro evaluation of DOTA-Tenatumomab conjugates for theranostic applications in tenascin expressing tumors.

Giannini G, Milazzo FM, Battistuzzi G, Rosi A, Anastasi AM, Petronzelli F, Albertoni C, Tei L, Leone L, Salvini L, De Santis R. Giannini G, et al. Among authors: de santis r. Bioorg Med Chem. 2019 Aug 1;27(15):3248-3253. doi: 10.1016/j.bmc.2019.05.047. Epub 2019 May 31. Bioorg Med Chem. 2019. PMID: 31208798 Free article.

5

ErbB2 Targeted Epigenetic Modulation: Anti-tumor Efficacy of the ADC Trastuzumab-HDACi ST8176AA1.

Milazzo FM, Vesci L, Anastasi AM, Chiapparino C, Rosi A, Giannini G, Taddei M, Cini E, Faltoni V, Petricci E, Battistuzzi G, Salvini L, Carollo V, De Santis R. Milazzo FM, et al. Among authors: de santis r. Front Oncol. 2020 Jan 23;9:1534. doi: 10.3389/fonc.2019.01534. eCollection 2019. Front Oncol. 2020. PMID: 32039017 Free PMC article.

6

Antibody drug conjugates with hydroxamic acid cargos for histone deacetylase (HDAC) inhibition.

Cianferotti C, Faltoni V, Cini E, Ermini E, Migliorini F, Petricci E, Taddei M, Salvini L, Battistuzzi G, Milazzo FM, Anastasi AM, Chiapparino C, De Santis R, Giannini G. Cianferotti C, et al. Among authors: de santis r. Chem Commun (Camb). 2021 Jan 28;57(7):867-870. doi: 10.1039/d0cc06131j. Chem Commun (Camb). 2021. PMID: 33433550

7

Intra-tumor AvidinOX allows efficacy of low dose systemic biotinylated Cetuximab in a model of head and neck cancer.

Vesci L, Milazzo FM, Anastasi AM, Petronzelli F, Chiapparino C, Carollo V, Roscilli G, Marra E, Luberto L, Aurisicchio L, Pacello ML, Spagnoli LG, De Santis R. Vesci L, et al. Among authors: de santis r. Oncotarget. 2016 Jan 5;7(1):914-28. doi: 10.18632/oncotarget.6089. Oncotarget. 2016. PMID: 26575422 Free PMC article.

8

AvidinOX-anchored biotinylated trastuzumab and pertuzumab induce down-modulation of ErbB2 and tumor cell death at concentrations order of magnitude lower than not-anchored antibodies.

Milazzo FM, Anastasi AM, Chiapparino C, Rosi A, Leoni B, Vesci L, Petronzelli F, De Santis R. Milazzo FM, et al. Among authors: de santis r. Oncotarget. 2017 Apr 4;8(14):22590-22605. doi: 10.18632/oncotarget.15145. Oncotarget. 2017. PMID: 28186982 Free PMC article.

9

Antibody drug conjugates (ADCs) charged with HDAC inhibitor for targeted epigenetic modulation.

Cini E, Faltoni V, Petricci E, Taddei M, Salvini L, Giannini G, Vesci L, Milazzo FM, Anastasi AM, Battistuzzi G, De Santis R. Cini E, et al. Among authors: de santis r. Chem Sci. 2018 Jul 3;9(31):6490-6496. doi: 10.1039/c7sc05266a. eCollection 2018 Aug 21. Chem Sci. 2018. PMID: 30288233 Free PMC article.

10

Preclinical pharmacology and safety of a novel avidin derivative for tissue-targeted delivery of radiolabelled biotin.

Petronzelli F, Anastasi AM, Pelliccia A, Santapaola D, Albertoni C, Rosi A, Leoni B, Ferrari LE, Paganelli G, Gramiccioli G, Pesce D, Alfano AM, Stasi MA, De Santis R. Petronzelli F, et al. Among authors: de santis r. Basic Clin Pharmacol Toxicol. 2011 Sep;109(3):145-55. doi: 10.1111/j.1742-7843.2011.00701.x. Epub 2011 Apr 25. Basic Clin Pharmacol Toxicol. 2011. PMID: 21426491 Free article.

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