De Luca A - Search Results

1

Blockers of Skeletal Muscle Na_v1.4 Channels: From Therapy of Myotonic Syndrome to Molecular Determinants of Pharmacological Action and Back.

De Bellis M, Boccanegra B, Cerchiara AG, Imbrici P, De Luca A. De Bellis M, et al. Among authors: de luca a. Int J Mol Sci. 2023 Jan 3;24(1):857. doi: 10.3390/ijms24010857. Int J Mol Sci. 2023. PMID: 36614292 Free PMC article. Review.

2

Evaluation of the antimyotonic activity of mexiletine and some new analogs on sodium currents of single muscle fibers and on the abnormal excitability of the myotonic ADR mouse.

De Luca A, Pierno S, Natuzzi F, Franchini C, Duranti A, Lentini G, Tortorella V, Jockusch H, Camerino DC. De Luca A, et al. J Pharmacol Exp Ther. 1997 Jul;282(1):93-100. J Pharmacol Exp Ther. 1997. PMID: 9223544

3

Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide.

De Luca A, Natuzzi F, Falcone G, Duranti A, Lentini G, Franchini C, Tortorella V, Camerino DC. De Luca A, et al. Naunyn Schmiedebergs Arch Pharmacol. 1997 Dec;356(6):777-87. doi: 10.1007/pl00005118. Naunyn Schmiedebergs Arch Pharmacol. 1997. PMID: 9453464

4

Partial recovery of skeletal muscle sodium channel properties in aged rats chronically treated with growth hormone or the GH-secretagogue hexarelin.

Desaphy JF, De Luca A, Pierno S, Imbrici P, Camerino DC. Desaphy JF, et al. Among authors: de luca a. J Pharmacol Exp Ther. 1998 Aug;286(2):903-12. J Pharmacol Exp Ther. 1998. PMID: 9694949

5

Modification by ageing of the tetrodotoxin-sensitive sodium channels in rat skeletal muscle fibres.

Desaphy JF, De Luca A, Imbrici P, Conte Camerino D. Desaphy JF, et al. Among authors: de luca a. Biochim Biophys Acta. 1998 Aug 14;1373(1):37-46. doi: 10.1016/s0005-2736(98)00085-6. Biochim Biophys Acta. 1998. PMID: 9733912 Free article.

6

Effect of mexiletine on sea anemone toxin-induced non-inactivating sodium channels of rat skeletal muscle: a model of sodium channel myotonia.

Desaphy JF, Camerino DC, Tortorella V, De Luca A. Desaphy JF, et al. Among authors: de luca a. Neuromuscul Disord. 1999 May;9(3):182-9. doi: 10.1016/s0960-8966(98)00115-1. Neuromuscul Disord. 1999. PMID: 10382914

7

Increased hindrance on the chiral carbon atom of mexiletine enhances the block of rat skeletal muscle Na+ channels in a model of myotonia induced by ATX.

Desaphy JF, Conte Camerino D, Franchini C, Lentini G, Tortorella V, De Luca A. Desaphy JF, et al. Among authors: de luca a. Br J Pharmacol. 1999 Nov;128(6):1165-74. doi: 10.1038/sj.bjp.0702901. Br J Pharmacol. 1999. PMID: 10578128 Free PMC article.

8

Molecular determinants of mexiletine structure for potent and use-dependent block of skeletal muscle sodium channels.

De Luca A, Natuzzi F, Desaphy JF, Loni G, Lentini G, Franchini C, Tortorella V, Camerino DC. De Luca A, et al. Mol Pharmacol. 2000 Feb;57(2):268-77. Mol Pharmacol. 2000. PMID: 10648636

9

Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo.

Talon S, De Luca A, De Bellis M, Desaphy JF, Lentini G, Scilimati A, Corbo F, Franchini C, Tortorella P, Jockusch H, Conte Camerino D. Talon S, et al. Among authors: de luca a, de bellis m. Br J Pharmacol. 2001 Dec;134(7):1523-31. doi: 10.1038/sj.bjp.0704366. Br J Pharmacol. 2001. PMID: 11724759 Free PMC article.

10

Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse.

Pierno S, Desaphy JF, Liantonio A, De Bellis M, Bianco G, De Luca A, Frigeri A, Nicchia GP, Svelto M, Léoty C, George AL Jr, Camerino DC. Pierno S, et al. Among authors: de luca a, de bellis m. Brain. 2002 Jul;125(Pt 7):1510-21. doi: 10.1093/brain/awf162. Brain. 2002. PMID: 12077001

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