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A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy.
Eteläinen TS, Silva MC, Uhari-Väänänen JK, De Lorenzo F, Jäntti MH, Cui H, Chavero-Pieres M, Kilpeläinen T, Mechtler C, Svarcbahs R, Seppälä E, Savinainen JR, Puris E, Fricker G, Gynther M, Julku UH, Huttunen HJ, Haggarty SJ, Myöhänen TT. Eteläinen TS, et al. Among authors: de lorenzo f. Sci Transl Med. 2023 Apr 12;15(691):eabq2915. doi: 10.1126/scitranslmed.abq2915. Epub 2023 Apr 12. Sci Transl Med. 2023. PMID: 37043557
Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model.
Eteläinen TS, Kilpeläinen TP, Ignatius A, Auno S, De Lorenzo F, Uhari-Väänänen JK, Julku UH, Myöhänen TT. Eteläinen TS, et al. Among authors: de lorenzo f. Neuropharmacology. 2022 Nov 1;218:109213. doi: 10.1016/j.neuropharm.2022.109213. Epub 2022 Aug 12. Neuropharmacology. 2022. PMID: 35964686 Free article.
5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein-Protein Interaction-Derived Functions.
Pätsi HT, Kilpeläinen TP, Jumppanen M, Uhari-Väänänen J, Wielendaele PV, De Lorenzo F, Cui H, Auno S, Saharinen J, Seppälä E, Sipari N, Savinainen J, De Meester I, Lambeir AM, Lahtela-Kakkonen M, Myöhänen TT, Wallén EAA. Pätsi HT, et al. Among authors: de lorenzo f. J Med Chem. 2024 Apr 11;67(7):5421-5436. doi: 10.1021/acs.jmedchem.3c01993. Epub 2024 Mar 28. J Med Chem. 2024. PMID: 38546708
CDNF rescues motor neurons in models of amyotrophic lateral sclerosis by targeting endoplasmic reticulum stress.
De Lorenzo F, Lüningschrör P, Nam J, Beckett L, Pilotto F, Galli E, Lindholm P, Rüdt von Collenberg C, Mungwa ST, Jablonka S, Kauder J, Thau-Habermann N, Petri S, Lindholm D, Saxena S, Sendtner M, Saarma M, Voutilainen MH. De Lorenzo F, et al. Brain. 2023 Sep 1;146(9):3783-3799. doi: 10.1093/brain/awad087. Brain. 2023. PMID: 36928391 Free PMC article.
Evidence for an Additive Neurorestorative Effect of Simultaneously Administered CDNF and GDNF in Hemiparkinsonian Rats: Implications for Different Mechanism of Action.
Voutilainen MH, De Lorenzo F, Stepanova P, Bäck S, Yu LY, Lindholm P, Pörsti E, Saarma M, Männistö PT, Tuominen RK. Voutilainen MH, et al. Among authors: de lorenzo f. eNeuro. 2017 Mar 13;4(1):ENEURO.0117-16.2017. doi: 10.1523/ENEURO.0117-16.2017. eCollection 2017 Jan-Feb. eNeuro. 2017. PMID: 28303260 Free PMC article.
Demographic Analysis of Cancer Research Priorities and Treatment Correlations.
Horgan D, Van den Bulcke M, Malapelle U, Normanno N, Capoluongo ED, Prelaj A, Rizzari C, Stathopoulou A, Singh J, Kozaric M, Dube F, Ottaviano M, Boccia S, Pravettoni G, Cattaneo I, Malats N, Buettner R, Lekadir K, de Lorenzo F, Alix-Panabieres C, Badreh S, Solary E, De Maria R, Hofman P. Horgan D, et al. Among authors: de lorenzo f. Curr Oncol. 2024 Mar 29;31(4):1839-1864. doi: 10.3390/curroncol31040139. Curr Oncol. 2024. PMID: 38668042 Free PMC article.
Management of patients with rare adult solid cancers: objectives and evaluation of European reference networks (ERN) EURACAN.
Blay JY, Casali P, Ray-Coquard I, Seckl MJ, Gietema J, de Herder WW, Caplin M, Klümpen HJ, Glehen O, Wyrwicz L, Peeters R, Licitra L, Girard N, Piperno-Neumann S, Kapiteijn E, Idbaih A, Franceschi E, Trama A, Frezza AM, Hohenberger P, Hindi N, Martin-Broto J, Schell J, Rogasik M, Lejeune S, Oliver K, de Lorenzo F, Weinman A. Blay JY, et al. Among authors: de lorenzo f. Lancet Reg Health Eur. 2024 Feb 16;39:100861. doi: 10.1016/j.lanepe.2024.100861. eCollection 2024 Apr. Lancet Reg Health Eur. 2024. PMID: 38384730 Free PMC article. Review.
Aligning Cancer Research Priorities in Europe with Recommendations for Conquering Cancer: A Comprehensive Analysis.
Horgan D, Bulcke MVD, Malapelle U, Normanno N, Capoluongo ED, Prelaj A, Rizzari C, Stathopoulou A, Singh J, Kozaric M, Dube F, Ottaviano M, Boccia S, Pravettoni G, Cattaneo I, Malats N, Buettner R, Lekadir K, de Lorenzo F, Blanc P, Alix-Panabieres C, Badreh S, Hofman P, Solary E, De Maria R. Horgan D, et al. Among authors: de lorenzo f. Healthcare (Basel). 2024 Jan 19;12(2):259. doi: 10.3390/healthcare12020259. Healthcare (Basel). 2024. PMID: 38275541 Free PMC article.
Tackling the implementation gap for the uptake of NGS and advanced molecular diagnostics into healthcare systems.
Horgan D, Van den Bulcke M, Malapelle U, Troncone G, Normanno N, Capoluongo ED, Prelaj A, Rizzari C, Trapani D, Singh J, Kozaric M, Longshore J, Ottaviano M, Boccia S, Pravettoni G, Cattaneo I, Malats N, Buettner R, Lekadir K, de Lorenzo F, Hofman P, De Maria R. Horgan D, et al. Among authors: de lorenzo f. Heliyon. 2023 Dec 20;10(1):e23914. doi: 10.1016/j.heliyon.2023.e23914. eCollection 2024 Jan 15. Heliyon. 2023. PMID: 38234913 Free PMC article.
Strategies to decrease inequalities in cancer therapeutics, care and prevention: Proceedings on a conference organized by the Pontifical Academy of Sciences and the European Academy of Cancer Sciences, Vatican City, February 23-24, 2023.
Ringborg U, von Braun J, Celis J, Baumann M, Berns A, Eggermont A, Heard E, Heitor M, Chandy M, Chen CJ, Costa A, De Lorenzo F, De Robertis EM, Dubee FC, Ernberg I, Gabriel M, Helland Å, Henrique R, Jönsson B, Kallioniemi O, Korbel J, Krause M, Lowy DR, Michielin O, Nagy P, Oberst S, Paglia V, Parker MI, Ryan K, Sawyers CL, Schüz J, Silkaitis K, Solary E, Thomas D, Turkson P, Weiderpass E, Yang H. Ringborg U, et al. Among authors: de lorenzo f. Mol Oncol. 2024 Feb;18(2):245-279. doi: 10.1002/1878-0261.13575. Epub 2024 Jan 22. Mol Oncol. 2024. PMID: 38135904 Free PMC article.
174 results