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Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia.
Lindhurst MJ, Fiermonte G, Song S, Struys E, De Leonardis F, Schwartzberg PL, Chen A, Castegna A, Verhoeven N, Mathews CK, Palmieri F, Biesecker LG. Lindhurst MJ, et al. Among authors: de leonardis f. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15927-32. doi: 10.1073/pnas.0607661103. Epub 2006 Oct 11. Proc Natl Acad Sci U S A. 2006. PMID: 17035501 Free PMC article.
MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria.
Zaltsman Y, Shachnai L, Yivgi-Ohana N, Schwarz M, Maryanovich M, Houtkooper RH, Vaz FM, De Leonardis F, Fiermonte G, Palmieri F, Gillissen B, Daniel PT, Jimenez E, Walsh S, Koehler CM, Roy SS, Walter L, Hajnóczky G, Gross A. Zaltsman Y, et al. Among authors: de leonardis f. Nat Cell Biol. 2010 Jun;12(6):553-562. doi: 10.1038/ncb2057. Epub 2010 May 2. Nat Cell Biol. 2010. PMID: 20436477 Free PMC article.
UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation.
Vozza A, Parisi G, De Leonardis F, Lasorsa FM, Castegna A, Amorese D, Marmo R, Calcagnile VM, Palmieri L, Ricquier D, Paradies E, Scarcia P, Palmieri F, Bouillaud F, Fiermonte G. Vozza A, et al. Among authors: de leonardis f. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):960-5. doi: 10.1073/pnas.1317400111. Epub 2014 Jan 6. Proc Natl Acad Sci U S A. 2014. PMID: 24395786 Free PMC article.
Biochemical characterization of a new mitochondrial transporter of dephosphocoenzyme A in Drosophila melanogaster.
Vozza A, De Leonardis F, Paradies E, De Grassi A, Pierri CL, Parisi G, Marobbio CMT, Lasorsa FM, Muto L, Capobianco L, Dolce V, Raho S, Fiermonte G. Vozza A, et al. Among authors: de leonardis f, de grassi a. Biochim Biophys Acta Bioenerg. 2017 Feb;1858(2):137-146. doi: 10.1016/j.bbabio.2016.11.006. Epub 2016 Nov 9. Biochim Biophys Acta Bioenerg. 2017. PMID: 27836698 Free article.
KRAS-regulated glutamine metabolism requires UCP2-mediated aspartate transport to support pancreatic cancer growth.
Raho S, Capobianco L, Malivindi R, Vozza A, Piazzolla C, De Leonardis F, Gorgoglione R, Scarcia P, Pezzuto F, Agrimi G, Barile SN, Pisano I, Reshkin SJ, Greco MR, Cardone RA, Rago V, Li Y, Marobbio CMT, Sommergruber W, Riley CL, Lasorsa FM, Mills E, Vegliante MC, De Benedetto GE, Fratantonio D, Palmieri L, Dolce V, Fiermonte G. Raho S, et al. Among authors: de benedetto ge, de leonardis f. Nat Metab. 2020 Dec;2(12):1373-1381. doi: 10.1038/s42255-020-00315-1. Epub 2020 Nov 23. Nat Metab. 2020. PMID: 33230296
The mitochondrial aspartate/glutamate carrier (AGC or Aralar1) isoforms in D. melanogaster: biochemical characterization, gene structure, and evolutionary analysis.
Lunetti P, Marsano RM, Curcio R, Dolce V, Fiermonte G, Cappello AR, Marra F, Moschetti R, Li Y, Aiello D, Del Arco Martínez A, Lauria G, De Leonardis F, Ferramosca A, Zara V, Capobianco L. Lunetti P, et al. Among authors: de leonardis f. Biochim Biophys Acta Gen Subj. 2021 May;1865(5):129854. doi: 10.1016/j.bbagen.2021.129854. Epub 2021 Jan 23. Biochim Biophys Acta Gen Subj. 2021. PMID: 33497735
Human mitochondrial uncoupling protein 3 functions as a metabolite transporter.
De Leonardis F, Ahmed A, Vozza A, Capobianco L, Riley CL, Barile SN, Di Molfetta D, Tiziani S, DiGiovanni J, Palmieri L, Dolce V, Fiermonte G. De Leonardis F, et al. FEBS Lett. 2024 Feb;598(3):338-346. doi: 10.1002/1873-3468.14784. Epub 2023 Dec 11. FEBS Lett. 2024. PMID: 38058167
132 results