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mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells.
Bevers S, Kooijmans SAA, Van de Velde E, Evers MJW, Seghers S, Gitz-Francois JJJM, van Kronenburg NCH, Fens MHAM, Mastrobattista E, Hassler L, Sork H, Lehto T, Ahmed KE, El Andaloussi S, Fiedler K, Breckpot K, Maes M, Van Hoorick D, Bastogne T, Schiffelers RM, De Koker S. Bevers S, et al. Among authors: de koker s. Mol Ther. 2022 Sep 7;30(9):3078-3094. doi: 10.1016/j.ymthe.2022.07.007. Epub 2022 Jul 12. Mol Ther. 2022. PMID: 35821637 Free PMC article.
Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses.
De Beuckelaer A, Pollard C, Van Lint S, Roose K, Van Hoecke L, Naessens T, Udhayakumar VK, Smet M, Sanders N, Lienenklaus S, Saelens X, Weiss S, Vanham G, Grooten J, De Koker S. De Beuckelaer A, et al. Among authors: de koker s. Mol Ther. 2016 Nov;24(11):2012-2020. doi: 10.1038/mt.2016.161. Epub 2016 Aug 10. Mol Ther. 2016. PMID: 27506450 Free PMC article.
Post-PEGylated and crosslinked polymeric ssRNA nanocomplexes as adjuvants targeting lymph nodes with increased cytolytic T cell inducing properties.
Lou B, De Beuckelaer A, Dakwar GR, Remaut K, Grooten J, Braeckmans K, De Geest BG, Mastrobattista E, De Koker S, Hennink WE. Lou B, et al. Among authors: de beuckelaer a, de geest bg, de koker s. J Control Release. 2018 Aug 28;284:73-83. doi: 10.1016/j.jconrel.2018.06.010. Epub 2018 Jun 15. J Control Release. 2018. PMID: 29908893
Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety.
Van der Jeught K, De Koker S, Bialkowski L, Heirman C, Tjok Joe P, Perche F, Maenhout S, Bevers S, Broos K, Deswarte K, Malard V, Hammad H, Baril P, Benvegnu T, Jaffrès PA, Kooijmans SAA, Schiffelers R, Lienenklaus S, Midoux P, Pichon C, Breckpot K, Thielemans K. Van der Jeught K, et al. Among authors: de koker s. ACS Nano. 2018 Oct 23;12(10):9815-9829. doi: 10.1021/acsnano.8b00966. Epub 2018 Oct 1. ACS Nano. 2018. PMID: 30256609 Free article.
60 results