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A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate.
Sanchez-Felipe L, Vercruysse T, Sharma S, Ma J, Lemmens V, Van Looveren D, Arkalagud Javarappa MP, Boudewijns R, Malengier-Devlies B, Liesenborghs L, Kaptein SJF, De Keyzer C, Bervoets L, Debaveye S, Rasulova M, Seldeslachts L, Li LH, Jansen S, Yakass MB, Verstrepen BE, Böszörményi KP, Kiemenyi-Kayere G, van Driel N, Quaye O, Zhang X, Ter Horst S, Mishra N, Deboutte W, Matthijnssens J, Coelmont L, Vandermeulen C, Heylen E, Vergote V, Schols D, Wang Z, Bogers W, Kuiken T, Verschoor E, Cawthorne C, Van Laere K, Opdenakker G, Vande Velde G, Weynand B, Teuwen DE, Matthys P, Neyts J, Jan Thibaut H, Dallmeier K. Sanchez-Felipe L, et al. Among authors: de keyzer c. Nature. 2021 Feb;590(7845):320-325. doi: 10.1038/s41586-020-3035-9. Epub 2020 Dec 1. Nature. 2021. PMID: 33260195
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2-infected hamsters, whereas hydroxychloroquine lacks activity.
Kaptein SJF, Jacobs S, Langendries L, Seldeslachts L, Ter Horst S, Liesenborghs L, Hens B, Vergote V, Heylen E, Barthelemy K, Maas E, De Keyzer C, Bervoets L, Rymenants J, Van Buyten T, Zhang X, Abdelnabi R, Pang J, Williams R, Thibaut HJ, Dallmeier K, Boudewijns R, Wouters J, Augustijns P, Verougstraete N, Cawthorne C, Breuer J, Solas C, Weynand B, Annaert P, Spriet I, Vande Velde G, Neyts J, Rocha-Pereira J, Delang L. Kaptein SJF, et al. Among authors: de keyzer c. Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26955-26965. doi: 10.1073/pnas.2014441117. Epub 2020 Oct 9. Proc Natl Acad Sci U S A. 2020. PMID: 33037151 Free PMC article.
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.
Boudewijns R, Thibaut HJ, Kaptein SJF, Li R, Vergote V, Seldeslachts L, Van Weyenbergh J, De Keyzer C, Bervoets L, Sharma S, Liesenborghs L, Ma J, Jansen S, Van Looveren D, Vercruysse T, Wang X, Jochmans D, Martens E, Roose K, De Vlieger D, Schepens B, Van Buyten T, Jacobs S, Liu Y, Martí-Carreras J, Vanmechelen B, Wawina-Bokalanga T, Delang L, Rocha-Pereira J, Coelmont L, Chiu W, Leyssen P, Heylen E, Schols D, Wang L, Close L, Matthijnssens J, Van Ranst M, Compernolle V, Schramm G, Van Laere K, Saelens X, Callewaert N, Opdenakker G, Maes P, Weynand B, Cawthorne C, Vande Velde G, Wang Z, Neyts J, Dallmeier K. Boudewijns R, et al. Among authors: de keyzer c. Nat Commun. 2020 Nov 17;11(1):5838. doi: 10.1038/s41467-020-19684-y. Nat Commun. 2020. PMID: 33203860 Free PMC article.
Updated vaccine protects against SARS-CoV-2 variants including Omicron (B.1.1.529) and prevents transmission in hamsters.
Sharma S, Vercruysse T, Sanchez-Felipe L, Kerstens W, Rasulova M, Bervoets L, De Keyzer C, Abdelnabi R, Foo CS, Lemmens V, Van Looveren D, Maes P, Baele G, Weynand B, Lemey P, Neyts J, Thibaut HJ, Dallmeier K. Sharma S, et al. Among authors: de keyzer c. Nat Commun. 2022 Nov 4;13(1):6644. doi: 10.1038/s41467-022-34439-7. Nat Commun. 2022. PMID: 36333374 Free PMC article.
Posaconazole inhibits multiple steps of the alphavirus replication cycle.
Varghese FS, Meutiawati F, Teppor M, Jacobs S, de Keyzer C, Taşköprü E, van Woudenbergh E, Overheul GJ, Bouma E, Smit JM, Delang L, Merits A, van Rij RP. Varghese FS, et al. Among authors: de keyzer c. Antiviral Res. 2022 Jan;197:105223. doi: 10.1016/j.antiviral.2021.105223. Epub 2021 Nov 29. Antiviral Res. 2022. PMID: 34856248 Free article.
A roadmap for urban evolutionary ecology.
Rivkin LR, Santangelo JS, Alberti M, Aronson MFJ, de Keyzer CW, Diamond SE, Fortin MJ, Frazee LJ, Gorton AJ, Hendry AP, Liu Y, Losos JB, MacIvor JS, Martin RA, McDonnell MJ, Miles LS, Munshi-South J, Ness RW, Newman AEM, Stothart MR, Theodorou P, Thompson KA, Verrelli BC, Whitehead A, Winchell KM, Johnson MTJ. Rivkin LR, et al. Among authors: de keyzer cw. Evol Appl. 2018 Dec 14;12(3):384-398. doi: 10.1111/eva.12734. eCollection 2019 Mar. Evol Appl. 2018. PMID: 30828362 Free PMC article.