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Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects.
Saul S, Karim M, Ghita L, Huang PT, Chiu W, Durán V, Lo CW, Kumar S, Bhalla N, Leyssen P, Alem F, Boghdeh NA, Tran DH, Cohen CA, Brown JA, Huie KE, Tindle C, Sibai M, Ye C, Khalil AM, Chiem K, Martinez-Sobrido L, Dye JM, Pinsky BA, Ghosh P, Das S, Solow-Cordero DE, Jin J, Wikswo JP, Jochmans D, Neyts J, De Jonghe S, Narayanan A, Einav S. Saul S, et al. Among authors: de jonghe s. J Clin Invest. 2023 Oct 2;133(19):e169510. doi: 10.1172/JCI169510. J Clin Invest. 2023. PMID: 37581931 Free PMC article.
Synthesis and evaluation of 6-aza-2'-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis.
Kögler M, Busson R, De Jonghe S, Rozenski J, Van Belle K, Louat T, Munier-Lehmann H, Herdewijn P. Kögler M, et al. Among authors: de jonghe s. Chem Biodivers. 2012 Mar;9(3):536-56. doi: 10.1002/cbdv.201100285. Chem Biodivers. 2012. PMID: 22422522
Synthesis and in vitro evaluation of 2-amino-4-N-piperazinyl-6-(3,4-dimethoxyphenyl)-pteridines as dual immunosuppressive and anti-inflammatory agents.
De Jonghe S, Marchand A, Gao LJ, Calleja A, Cuveliers E, Sienaert I, Herman J, Clydesdale G, Sefrioui H, Lin Y, Pfleiderer W, Waer M, Herdewijn P. De Jonghe S, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):145-9. doi: 10.1016/j.bmcl.2010.11.053. Epub 2010 Nov 16. Bioorg Med Chem Lett. 2011. PMID: 21131199 Free article.
Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues.
De Jonghe S, Van Overmeire I, Gunst J, De Bruyn A, Hendrix C, Van Calenbergh S, Busson R, De Keukeleire D, Philippé J, Herdewijn P. De Jonghe S, et al. Among authors: de bruyn a, de keukeleire d. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3159-64. doi: 10.1016/s0960-894x(99)00553-3. Bioorg Med Chem Lett. 1999. PMID: 10560744
Correction to Bicyclic α-Iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer's Disease.
Abás S, Rodríguez-Arévalo S, Bagán A, Griñán-Ferré C, Vasilopoulou F, Brocos-Mosquera I, Muguruza C, Pérez B, Molins E, Luque FJ, Pérez-Lozano P, de Jonghe S, Daelemans D, Naesens L, Brea J, Loza MI, Hernández-Hernández E, García-Sevilla JA, García-Fuster MJ, Radan M, Djikic T, Nikolic K, Pallàs M, Callado LF, Escolano C. Abás S, et al. Among authors: de jonghe s. J Med Chem. 2020 Sep 24;63(18):10529. doi: 10.1021/acs.jmedchem.0c01324. Epub 2020 Sep 14. J Med Chem. 2020. PMID: 32924503 No abstract available.
Synthesis and Structure-Activity Relationship Studies of Benzo[b][1,4]oxazin-3(4H)-one Analogues as Inhibitors of Mycobacterial Thymidylate Synthase X.
Modranka J, Li J, Parchina A, Vanmeert M, Dumbre S, Salman M, Myllykallio H, Becker HF, Vanhoutte R, Margamuljana L, Nguyen H, Abu El-Asrar R, Rozenski J, Herdewijn P, De Jonghe S, Lescrinier E. Modranka J, et al. Among authors: de jonghe s. ChemMedChem. 2019 Mar 22;14(6):645-662. doi: 10.1002/cmdc.201800739. Epub 2019 Feb 20. ChemMedChem. 2019. PMID: 30702807
147 results