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Structure-guided design of pyridoclax derivatives based on Noxa / Mcl-1 interaction mode.
Hedir S, De Giorgi M, Fogha J, De Pascale M, Weiswald LB, Brotin E, Marekha B, Denoyelle C, Denis C, Suzanne P, Gautier F, Juin P, Ligat L, Lopez F, Carlier L, Legay R, Bureau R, Rault S, Poulain L, Oliveira Santos JS, Voisin-Chiret AS. Hedir S, et al. Among authors: de pascale m, de giorgi m. Eur J Med Chem. 2018 Nov 5;159:357-380. doi: 10.1016/j.ejmech.2018.10.003. Epub 2018 Oct 4. Eur J Med Chem. 2018. PMID: 30308410
First evidence that oligopyridines, α-helix foldamers, inhibit Mcl-1 and sensitize ovarian carcinoma cells to Bcl-xL-targeting strategies.
Gloaguen C, Voisin-Chiret AS, Sopkova-de Oliveira Santos J, Fogha J, Gautier F, De Giorgi M, Burzicki G, Perato S, Pétigny-Lechartier C, Simonin-Le Jeune K, Brotin E, Goux D, N'Diaye M, Lambert B, Louis MH, Ligat L, Lopez F, Juin P, Bureau R, Rault S, Poulain L. Gloaguen C, et al. Among authors: de giorgi m. J Med Chem. 2015 Feb 26;58(4):1644-68. doi: 10.1021/jm500672y. Epub 2015 Feb 4. J Med Chem. 2015. PMID: 25585174
Toward Understanding Mcl-1 Promiscuous and Specific Binding Mode.
Fogha J, Marekha B, De Giorgi M, Voisin-Chiret AS, Rault S, Bureau R, Sopkova-de Oliveira Santos J. Fogha J, et al. Among authors: de giorgi m. J Chem Inf Model. 2017 Nov 27;57(11):2885-2895. doi: 10.1021/acs.jcim.7b00396. Epub 2017 Oct 27. J Chem Inf Model. 2017. PMID: 29016132
Synthesis of Pyridoclax Analogues: Insight into Their Druggability by Investigating Their Physicochemical Properties and Interactions with Membranes.
De Pascale M, Iacopetta D, Since M, Corvaisier S, Vie V, Paboeuf G, Hennequin D, Perato S, De Giorgi M, Sinicropi MS, Sopkova-De Oliveira Santos J, Voisin-Chiret AS, Malzert-Freon A. De Pascale M, et al. Among authors: de giorgi m. ChemMedChem. 2020 Jan 7;15(1):136-154. doi: 10.1002/cmdc.201900542. Epub 2019 Nov 26. ChemMedChem. 2020. PMID: 31743599 Free article.
Solubilization of α-galactosylceramide in aqueous medium: Impact on Natural Killer T cell activation and antitumor responses.
Macho-Fernandez E, Chekkat N, Ehret C, Thomann JS, De Giorgi M, Spanedda MV, Bourel-Bonnet L, Betbeder D, Heurtault B, Faveeuw C, Fournel S, Frisch B, Trottein F. Macho-Fernandez E, et al. Among authors: de giorgi m. Int J Pharm. 2017 Sep 15;530(1-2):354-363. doi: 10.1016/j.ijpharm.2017.07.054. Epub 2017 Jul 22. Int J Pharm. 2017. PMID: 28743554
Coupling of Ligands to the Liposome Surface by Click Chemistry.
Spanedda MV, De Giorgi M, Hassane FS, Schuber F, Bourel-Bonnet L, Frisch B. Spanedda MV, et al. Among authors: de giorgi m. Methods Mol Biol. 2017;1522:93-106. doi: 10.1007/978-1-4939-6591-5_8. Methods Mol Biol. 2017. PMID: 27837533
Step-by-step build-up of covalent poly(ethylene oxide) nanogel films.
Zahouani S, Hurman L, De Giorgi M, Vigier-Carrière C, Boulmedais F, Senger B, Frisch B, Schaaf P, Lavalle P, Jierry L. Zahouani S, et al. Among authors: de giorgi m. Nanoscale. 2017 Nov 30;9(46):18379-18391. doi: 10.1039/c7nr05424f. Nanoscale. 2017. PMID: 29147710
154 results