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DNMT1-interacting RNAs block gene-specific DNA methylation.
Di Ruscio A, Ebralidze AK, Benoukraf T, Amabile G, Goff LA, Terragni J, Figueroa ME, De Figueiredo Pontes LL, Alberich-Jorda M, Zhang P, Wu M, D'Alò F, Melnick A, Leone G, Ebralidze KK, Pradhan S, Rinn JL, Tenen DG. Di Ruscio A, et al. Among authors: de figueiredo pontes ll. Nature. 2013 Nov 21;503(7476):371-6. doi: 10.1038/nature12598. Epub 2013 Oct 9. Nature. 2013. PMID: 24107992 Free PMC article.
Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression.
Yong KJ, Basseres DS, Welner RS, Zhang WC, Yang H, Yan B, Alberich-Jorda M, Zhang J, de Figueiredo-Pontes LL, Battelli C, Hetherington CJ, Ye M, Zhang H, Maroni G, O'Brien K, Magli MC, Borczuk AC, Varticovski L, Kocher O, Zhang P, Moon YC, Sydorenko N, Cao L, Davis TW, Thakkar BM, Soo RA, Iwama A, Lim B, Halmos B, Neuberg D, Tenen DG, Levantini E. Yong KJ, et al. Among authors: de figueiredo pontes ll. Sci Transl Med. 2016 Aug 3;8(350):350ra104. doi: 10.1126/scitranslmed.aad6066. Sci Transl Med. 2016. PMID: 27488898 Free PMC article.
C/EBPγ is dispensable for steady-state and emergency granulopoiesis.
Kardosova M, Zjablovskaja P, Danek P, Angelisova P, de Figueiredo-Pontes LL, Welner RS, Brdicka T, Lee S, Tenen DG, Alberich-Jorda M. Kardosova M, et al. Among authors: de figueiredo pontes ll. Haematologica. 2018 Aug;103(8):e331-e335. doi: 10.3324/haematol.2017.173781. Epub 2018 Mar 22. Haematologica. 2018. PMID: 29567783 Free PMC article. No abstract available.
Halofuginone has anti-proliferative effects in acute promyelocytic leukemia by modulating the transforming growth factor beta signaling pathway.
de Figueiredo-Pontes LL, Assis PA, Santana-Lemos BA, Jácomo RH, Lima AS, Garcia AB, Thomé CH, Araújo AG, Panepucci RA, Zago MA, Nagler A, Falcão RP, Rego EM. de Figueiredo-Pontes LL, et al. PLoS One. 2011;6(10):e26713. doi: 10.1371/journal.pone.0026713. Epub 2011 Oct 28. PLoS One. 2011. PMID: 22053203 Free PMC article.
Dual ALK and EGFR inhibition targets a mechanism of acquired resistance to the tyrosine kinase inhibitor crizotinib in ALK rearranged lung cancer.
Yamaguchi N, Lucena-Araujo AR, Nakayama S, de Figueiredo-Pontes LL, Gonzalez DA, Yasuda H, Kobayashi S, Costa DB. Yamaguchi N, et al. Among authors: de figueiredo pontes ll. Lung Cancer. 2014 Jan;83(1):37-43. doi: 10.1016/j.lungcan.2013.09.019. Epub 2013 Oct 14. Lung Cancer. 2014. PMID: 24199682 Free PMC article.
Halofuginone inhibits phosphorylation of SMAD-2 reducing angiogenesis and leukemia burden in an acute promyelocytic leukemia mouse model.
Assis PA, De Figueiredo-Pontes LL, Lima AS, Leão V, Cândido LA, Pintão CT, Garcia AB, Saggioro FP, Panepucci RA, Chahud F, Nagler A, Falcão RP, Rego EM. Assis PA, et al. Among authors: de figueiredo pontes ll. J Exp Clin Cancer Res. 2015 Jun 23;34(1):65. doi: 10.1186/s13046-015-0181-2. J Exp Clin Cancer Res. 2015. PMID: 26099922 Free PMC article.
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