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Oxidized analogs of Di(1H-indol-3-yl)methyl-4-substituted benzenes are NR4A1-dependent UPR inducers with potent and safe anti-cancer activity.
Sanchez M, Xia Z, Rico-Bautista E, Cao X, Cuddy M, Castro DJ, Correa RG, Chen L, Yu J, Bobkov A, Ruvolo V, Andreeff M, Oshima RG, Matsuzawa SI, Reed JC, Zhang XK, Hansel D, Wolf DA, Dawson MI. Sanchez M, et al. Among authors: dawson mi. Oncotarget. 2018 May 18;9(38):25057-25074. doi: 10.18632/oncotarget.25285. eCollection 2018 May 18. Oncotarget. 2018. PMID: 29861853 Free PMC article.
Analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. 2. Impact of 3-chloro group replacement on inhibition of proliferation and induction of apoptosis of leukemia and cancer cell lines.
Xia Z, Correa RG, Das JK, Farhana L, Castro DJ, Yu J, Oshima RG, Fontana JA, Reed JC, Dawson MI. Xia Z, et al. Among authors: dawson mi. J Med Chem. 2012 Jan 12;55(1):233-49. doi: 10.1021/jm2011436. Epub 2011 Dec 2. J Med Chem. 2012. PMID: 22136251
160 results