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The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network.
Neier SC, Ferrer A, Wilton KM, Smith SEP, Kelcher AMH, Pavelko KD, Canfield JM, Davis TR, Stiles RJ, Chen Z, McCluskey J, Burrows SR, Rossjohn J, Hebrink DM, Carmona EM, Limper AH, Kappes DJ, Wettstein PJ, Johnson AJ, Pease LR, Daniels MA, Neuhauser C, Gil D, Schrum AG. Neier SC, et al. Among authors: davis tr. Sci Immunol. 2019 Feb 15;4(32):eaal2201. doi: 10.1126/sciimmunol.aal2201. Sci Immunol. 2019. PMID: 30770409 Free PMC article.
Early expression of mature αβ TCR in CD4-CD8- T cell progenitors enables MHC to drive development of T-ALL bearing NOTCH mutations.
Laffey KG, Stiles RJ, Ludescher MJ, Davis TR, Khwaja SS, Bram RJ, Wettstein PJ, Ramachandran V, Parks CA, Reyes EE, Ferrer A, Canfield JM, Johnson CE, Hammer RD, Gil D, Schrum AG. Laffey KG, et al. Among authors: davis tr. Proc Natl Acad Sci U S A. 2022 Jul 5;119(27):e2118529119. doi: 10.1073/pnas.2118529119. Epub 2022 Jun 29. Proc Natl Acad Sci U S A. 2022. PMID: 35767640 Free PMC article.
208 results