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Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine.
Weber P, Thonhofer M, Averill S, Davies GJ, Santana AG, Müller P, Nasseri SA, Offen WA, Pabst BM, Paschke E, Schalli M, Torvisco A, Tschernutter M, Tysoe C, Windischhofer W, Withers SG, Wolfsgruber A, Wrodnigg TM, Stütz AE. Weber P, et al. Among authors: davies gj. Molecules. 2020 Sep 3;25(17):4025. doi: 10.3390/molecules25174025. Molecules. 2020. PMID: 32899288 Free PMC article.
Crystal structure of the family 7 endoglucanase I (Cel7B) from Humicola insolens at 2.2 A resolution and identification of the catalytic nucleophile by trapping of the covalent glycosyl-enzyme intermediate.
MacKenzie LF, Sulzenbacher G, Divne C, Jones TA, Wöldike HF, Schülein M, Withers SG, Davies GJ. MacKenzie LF, et al. Among authors: davies gj. Biochem J. 1998 Oct 15;335 ( Pt 2)(Pt 2):409-16. doi: 10.1042/bj3350409. Biochem J. 1998. PMID: 9761741 Free PMC article.
Substrate distortion by a beta-mannanase: snapshots of the Michaelis and covalent-intermediate complexes suggest a B(2,5) conformation for the transition state.
Ducros VM, Zechel DL, Murshudov GN, Gilbert HJ, Szabó L, Stoll D, Withers SG, Davies GJ. Ducros VM, et al. Among authors: davies gj. Angew Chem Int Ed Engl. 2002 Aug 2;41(15):2824-7. doi: 10.1002/1521-3773(20020802)41:15<2824::AID-ANIE2824>3.0.CO;2-G. Angew Chem Int Ed Engl. 2002. PMID: 12203498 No abstract available.
613 results