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Agathisflavone as a Single Therapy or in Association With Mesenchymal Stem Cells Improves Tissue Repair in a Spinal Cord Injury Model in Rats.
do Nascimento RP, de Jesus LB, Oliveira-Junior MS, Almeida AM, Moreira ELT, Paredes BD, David JM, Souza BSF, de Fátima D Costa M, Butt AM, Silva VDA, Costa SL. do Nascimento RP, et al. Among authors: david jm. Front Pharmacol. 2022 Apr 5;13:858190. doi: 10.3389/fphar.2022.858190. eCollection 2022. Front Pharmacol. 2022. PMID: 35479309 Free PMC article.
Agathisflavone, a flavonoid derived from Poincianella pyramidalis (Tul.), enhances neuronal population and protects against glutamate excitotoxicity.
Dos Santos Souza C, Grangeiro MS, Lima Pereira EP, Dos Santos CC, da Silva AB, Sampaio GP, Ribeiro Figueiredo DD, David JM, David JP, da Silva VDA, Butt AM, Lima Costa S. Dos Santos Souza C, et al. Among authors: david jp, david jm. Neurotoxicology. 2018 Mar;65:85-97. doi: 10.1016/j.neuro.2018.02.001. Epub 2018 Feb 6. Neurotoxicology. 2018. PMID: 29425760
Agathisflavone modulates astrocytic responses and increases the population of neurons in an in vitro model of traumatic brain injury.
de Amorim VCM, Júnior MSO, da Silva AB, David JM, David JPL, de Fátima Dias Costa M, Butt AM, da Silva VDA, Costa SL. de Amorim VCM, et al. Among authors: david jpl, david jm. Naunyn Schmiedebergs Arch Pharmacol. 2020 Oct;393(10):1921-1930. doi: 10.1007/s00210-020-01905-2. Epub 2020 May 22. Naunyn Schmiedebergs Arch Pharmacol. 2020. PMID: 32444988
Reverted effect of mesenchymal stem cells in glioblastoma treated with agathisflavone and its selective antitumoral effect on cell viability, migration, and differentiation via STAT3.
Nascimento RP, Dos Santos BL, da Silva KC, Amaral da Silva VD, de Fátima Costa M, David JM, David JP, Moura-Neto V, Oliveira MDN, Ulrich H, de Faria Lopes GP, Costa SL. Nascimento RP, et al. Among authors: david jp, david jm. J Cell Physiol. 2021 Jul;236(7):5022-5035. doi: 10.1002/jcp.30209. Epub 2020 Dec 23. J Cell Physiol. 2021. PMID: 33368262
The Flavonoid Agathisflavone Directs Brain Microglia/Macrophages to a Neuroprotective Anti-Inflammatory and Antioxidant State via Regulation of NLRP3 Inflammasome.
Dos Santos BL, Dos Santos CC, Soares JRP, da Silva KC, de Oliveira JVR, Pereira GS, de Araújo FM, Costa MFD, David JM, da Silva VDA, Butt AM, Costa SL. Dos Santos BL, et al. Among authors: david jm. Pharmaceutics. 2023 May 5;15(5):1410. doi: 10.3390/pharmaceutics15051410. Pharmaceutics. 2023. PMID: 37242652 Free PMC article.
219 results