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Development of selective inhibitors of phosphatidylinositol 3-kinase C2α.
Lo WT, Belabed H, Kücükdisli M, Metag J, Roske Y, Prokofeva P, Ohashi Y, Horatscheck A, Cirillo D, Krauss M, Schmied C, Neuenschwander M, von Kries JP, Médard G, Kuster B, Perisic O, Williams RL, Daumke O, Payrastre B, Severin S, Nazaré M, Haucke V. Lo WT, et al. Among authors: daumke o. Nat Chem Biol. 2023 Jan;19(1):18-27. doi: 10.1038/s41589-022-01118-z. Epub 2022 Sep 15. Nat Chem Biol. 2023. PMID: 36109648 Free PMC article.
Crystal structure of nucleotide-free dynamin.
Faelber K, Posor Y, Gao S, Held M, Roske Y, Schulze D, Haucke V, Noé F, Daumke O. Faelber K, et al. Among authors: daumke o. Nature. 2011 Sep 18;477(7366):556-60. doi: 10.1038/nature10369. Nature. 2011. PMID: 21927000
Structural insights into dynamin-mediated membrane fission.
Faelber K, Held M, Gao S, Posor Y, Haucke V, Noé F, Daumke O. Faelber K, et al. Among authors: daumke o. Structure. 2012 Oct 10;20(10):1621-8. doi: 10.1016/j.str.2012.08.028. Structure. 2012. PMID: 23063009 Free article. Review.
Crystal structure of the dynamin tetramer.
Reubold TF, Faelber K, Plattner N, Posor Y, Ketel K, Curth U, Schlegel J, Anand R, Manstein DJ, Noé F, Haucke V, Daumke O, Eschenburg S. Reubold TF, et al. Among authors: daumke o. Nature. 2015 Sep 17;525(7569):404-8. doi: 10.1038/nature14880. Epub 2015 Aug 24. Nature. 2015. PMID: 26302298
Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Arumughan A, Roske Y, Barth C, Forero LL, Bravo-Rodriguez K, Redel A, Kostova S, McShane E, Opitz R, Faelber K, Rau K, Mielke T, Daumke O, Selbach M, Sanchez-Garcia E, Rocks O, Panáková D, Heinemann U, Wanker EE. Arumughan A, et al. Among authors: daumke o. Nat Commun. 2016 Oct 20;7:13047. doi: 10.1038/ncomms13047. Nat Commun. 2016. PMID: 27762274 Free PMC article.
An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.
Schrade K, Tröger J, Eldahshan A, Zühlke K, Abdul Azeez KR, Elkins JM, Neuenschwander M, Oder A, Elkewedi M, Jaksch S, Andrae K, Li J, Fernandes J, Müller PM, Grunwald S, Marino SF, Vukićević T, Eichhorst J, Wiesner B, Weber M, Kapiloff M, Rocks O, Daumke O, Wieland T, Knapp S, von Kries JP, Klussmann E. Schrade K, et al. Among authors: daumke o. PLoS One. 2018 Jan 26;13(1):e0191423. doi: 10.1371/journal.pone.0191423. eCollection 2018. PLoS One. 2018. PMID: 29373579 Free PMC article.
A SEPT1-based scaffold is required for Golgi integrity and function.
Song K, Gras C, Capin G, Gimber N, Lehmann M, Mohd S, Puchkov D, Rödiger M, Wilhelmi I, Daumke O, Schmoranzer J, Schürmann A, Krauss M. Song K, et al. Among authors: daumke o. J Cell Sci. 2019 Feb 1;132(3):jcs225557. doi: 10.1242/jcs.225557. J Cell Sci. 2019. PMID: 30709970 Free PMC article.
Structural basis of phosphatidylinositol 3-kinase C2α function.
Lo WT, Zhang Y, Vadas O, Roske Y, Gulluni F, De Santis MC, Zagar AV, Stephanowitz H, Hirsch E, Liu F, Daumke O, Kudryashev M, Haucke V. Lo WT, et al. Among authors: daumke o. Nat Struct Mol Biol. 2022 Mar;29(3):218-228. doi: 10.1038/s41594-022-00730-w. Epub 2022 Mar 7. Nat Struct Mol Biol. 2022. PMID: 35256802 Free PMC article.
92 results