Pancreatic α-Amylase Controls Glucose Assimilation by Duodenal Retrieval through N-Glycan-specific Binding, Endocytosis, and Degradation.
Date K, Satoh A, Iida K, Ogawa H.
Date K, et al.
J Biol Chem. 2015 Jul 10;290(28):17439-50. doi: 10.1074/jbc.M114.594937. Epub 2015 May 28.
J Biol Chem. 2015.
PMID: 26023238
Free PMC article.
Mammalian pancreatic alpha-amylase binds specifically to glycoprotein N-glycans in the brush-border membrane to activate starch digestion, whereas it significantly inhibits glucose uptake by Na(+)/glucose cotransporter 1 (SGLT1) at high concentrations (Asanuma-Date, K …
Mammalian pancreatic alpha-amylase binds specifically to glycoprotein N-glycans in the brush-border membrane to activate starch digestion, w …