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Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5.
Hartmann J, Bajaj T, Klengel C, Chatzinakos C, Ebert T, Dedic N, McCullough KM, Lardenoije R, Joëls M, Meijer OC, McCann KE, Dudek SM, Sarabdjitsingh RA, Daskalakis NP, Klengel T, Gassen NC, Schmidt MV, Ressler KJ. Hartmann J, et al. Among authors: daskalakis np. Cell Rep. 2021 Jun 1;35(9):109185. doi: 10.1016/j.celrep.2021.109185. Cell Rep. 2021. PMID: 34077736 Free PMC article.
Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation.
Yehuda R, Daskalakis NP, Bierer LM, Bader HN, Klengel T, Holsboer F, Binder EB. Yehuda R, et al. Among authors: daskalakis np. Biol Psychiatry. 2016 Sep 1;80(5):372-80. doi: 10.1016/j.biopsych.2015.08.005. Epub 2015 Aug 12. Biol Psychiatry. 2016. PMID: 26410355
Recent Genetics and Epigenetics Approaches to PTSD.
Daskalakis NP, Rijal CM, King C, Huckins LM, Ressler KJ. Daskalakis NP, et al. Curr Psychiatry Rep. 2018 Apr 5;20(5):30. doi: 10.1007/s11920-018-0898-7. Curr Psychiatry Rep. 2018. PMID: 29623448 Free PMC article. Review.
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.
Nievergelt CM, Maihofer AX, Klengel T, Atkinson EG, Chen CY, Choi KW, Coleman JRI, Dalvie S, Duncan LE, Gelernter J, Levey DF, Logue MW, Polimanti R, Provost AC, Ratanatharathorn A, Stein MB, Torres K, Aiello AE, Almli LM, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegovic E, Babić D, Bækvad-Hansen M, Baker DG, Beckham JC, Bierut LJ, Bisson JI, Boks MP, Bolger EA, Børglum AD, Bradley B, Brashear M, Breen G, Bryant RA, Bustamante AC, Bybjerg-Grauholm J, Calabrese JR, Caldas-de-Almeida JM, Dale AM, Daly MJ, Daskalakis NP, Deckert J, Delahanty DL, Dennis MF, Disner SG, Domschke K, Dzubur-Kulenovic A, Erbes CR, Evans A, Farrer LA, Feeny NC, Flory JD, Forbes D, Franz CE, Galea S, Garrett ME, Gelaye B, Geuze E, Gillespie C, Uka AG, Gordon SD, Guffanti G, Hammamieh R, Harnal S, Hauser MA, Heath AC, Hemmings SMJ, Hougaard DM, Jakovljevic M, Jett M, Johnson EO, Jones I, Jovanovic T, Qin XJ, Junglen AG, Karstoft KI, Kaufman ML, Kessler RC, Khan A, Kimbrel NA, King AP, Koen N, Kranzler HR, Kremen WS, Lawford BR, Lebois LAM, Lewis CE, Linnstaedt SD, Lori A, Lugonja B, Luykx JJ, Lyons MJ, Maples-Keller J, Marmar C, Martin AR, Martin NG, Maurer D,… See abstract for full author list ➔ Nievergelt CM, et al. Among authors: daskalakis np. Nat Commun. 2019 Oct 8;10(1):4558. doi: 10.1038/s41467-019-12576-w. Nat Commun. 2019. PMID: 31594949 Free PMC article.
Intergenerational Effects of Maternal Holocaust Exposure on FKBP5 Methylation.
Bierer LM, Bader HN, Daskalakis NP, Lehrner A, Provençal N, Wiechmann T, Klengel T, Makotkine I, Binder EB, Yehuda R. Bierer LM, et al. Among authors: daskalakis np. Am J Psychiatry. 2020 Aug 1;177(8):744-753. doi: 10.1176/appi.ajp.2019.19060618. Epub 2020 Apr 21. Am J Psychiatry. 2020. PMID: 32312110
Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts.
Huckins LM, Chatzinakos C, Breen MS, Hartmann J, Klengel T, da Silva Almeida AC, Dobbyn A, Girdhar K, Hoffman GE, Klengel C, Logue MW, Lori A, Maihofer AX, Morrison FG, Nguyen HT, Park Y, Ruderfer D, Sloofman LG, van Rooij SJH; PTSD Working Group of Psychiatric Genomics Consortium; Baker DG, Chen CY, Cox N, Duncan LE, Geyer MA, Glatt SJ, Im HK, Risbrough VB, Smoller JW, Stein DJ, Yehuda R, Liberzon I, Koenen KC, Jovanovic T, Kellis M, Miller MW, Bacanu SA, Nievergelt CM, Buxbaum JD, Sklar P, Ressler KJ, Stahl EA, Daskalakis NP. Huckins LM, et al. Among authors: daskalakis np. Cell Rep. 2020 Jun 2;31(9):107716. doi: 10.1016/j.celrep.2020.107716. Cell Rep. 2020. PMID: 32492425 Free PMC article.
TWAS pathway method greatly enhances the number of leads for uncovering the molecular underpinnings of psychiatric disorders.
Chatzinakos C, Georgiadis F, Lee D, Cai N, Vladimirov VI, Docherty A, Webb BT, Riley BP, Flint J, Kendler KS, Daskalakis NP, Bacanu SA. Chatzinakos C, et al. Among authors: daskalakis np. Am J Med Genet B Neuropsychiatr Genet. 2020 Dec;183(8):454-463. doi: 10.1002/ajmg.b.32823. Epub 2020 Sep 21. Am J Med Genet B Neuropsychiatr Genet. 2020. PMID: 32954640 Free PMC article.
87 results