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Nonpungent N-AVAM Capsaicin Analogues and Cancer Therapy.
Richbart SD, Friedman JR, Brown KC, Gadepalli RS, Miles SL, Rimoldi JM, Rankin GO, Valentovic MA, Tirona MT, Finch PT, Hess JA, Dasgupta P. Richbart SD, et al. Among authors: dasgupta p. J Med Chem. 2021 Feb 11;64(3):1346-1361. doi: 10.1021/acs.jmedchem.0c01679. Epub 2021 Jan 28. J Med Chem. 2021. PMID: 33508189 Free PMC article.
MG624, an α7-nAChR antagonist, inhibits angiogenesis via the Egr-1/FGF2 pathway.
Brown KC, Lau JK, Dom AM, Witte TR, Luo H, Crabtree CM, Shah YH, Shiflett BS, Marcelo AJ, Proper NA, Hardman WE, Egleton RD, Chen YC, Mangiarua EI, Dasgupta P. Brown KC, et al. Among authors: dasgupta p. Angiogenesis. 2012 Mar;15(1):99-114. doi: 10.1007/s10456-011-9246-9. Epub 2011 Dec 25. Angiogenesis. 2012. PMID: 22198237
Nicotinic acetylcholine receptor signaling in atherogenesis.
Santanam N, Thornhill BA, Lau JK, Crabtree CM, Cook CR, Brown KC, Dasgupta P. Santanam N, et al. Among authors: dasgupta p. Atherosclerosis. 2012 Dec;225(2):264-73. doi: 10.1016/j.atherosclerosis.2012.07.041. Epub 2012 Aug 14. Atherosclerosis. 2012. PMID: 22929083 Review.
Inhibition of cholinergic signaling causes apoptosis in human bronchioalveolar carcinoma.
Lau JK, Brown KC, Thornhill BA, Crabtree CM, Dom AM, Witte TR, Hardman WE, McNees CA, Stover CA, Carpenter AB, Luo H, Chen YC, Shiflett BS, Dasgupta P. Lau JK, et al. Among authors: dasgupta p. Cancer Res. 2013 Feb 15;73(4):1328-39. doi: 10.1158/0008-5472.CAN-12-3190. Epub 2012 Dec 7. Cancer Res. 2013. PMID: 23222296 Free PMC article.
Nicotine induces the up-regulation of the α7-nicotinic receptor (α7-nAChR) in human squamous cell lung cancer cells via the Sp1/GATA protein pathway.
Brown KC, Perry HE, Lau JK, Jones DV, Pulliam JF, Thornhill BA, Crabtree CM, Luo H, Chen YC, Dasgupta P. Brown KC, et al. Among authors: dasgupta p. J Biol Chem. 2013 Nov 15;288(46):33049-59. doi: 10.1074/jbc.M113.501601. Epub 2013 Oct 2. J Biol Chem. 2013. PMID: 24089524 Free PMC article. Clinical Trial.
Capsaicin induces apoptosis in human small cell lung cancer via the TRPV6 receptor and the calpain pathway.
Lau JK, Brown KC, Dom AM, Witte TR, Thornhill BA, Crabtree CM, Perry HE, Brown JM, Ball JG, Creel RG, Damron CL, Rollyson WD, Stevenson CD, Hardman WE, Valentovic MA, Carpenter AB, Dasgupta P. Lau JK, et al. Among authors: dasgupta p. Apoptosis. 2014 Aug;19(8):1190-201. doi: 10.1007/s10495-014-1007-y. Apoptosis. 2014. PMID: 24878626 Free PMC article.
1,318 results