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Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow.
Sun X, Sharma S, Fratz S, Kumar S, Rafikov R, Aggarwal S, Rafikova O, Lu Q, Burns T, Dasarathy S, Wright J, Schreiber C, Radman M, Fineman JR, Black SM. Sun X, et al. Among authors: dasarathy s. Antioxid Redox Signal. 2013 May 10;18(14):1739-52. doi: 10.1089/ars.2012.4806. Epub 2013 Mar 14. Antioxid Redox Signal. 2013. PMID: 23244702 Free PMC article.
Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric oxide synthase.
Sun X, Kumar S, Sharma S, Aggarwal S, Lu Q, Gross C, Rafikova O, Lee SG, Dasarathy S, Hou Y, Meadows ML, Han W, Su Y, Fineman JR, Black SM. Sun X, et al. Among authors: dasarathy s. Am J Respir Cell Mol Biol. 2014 Jun;50(6):1084-95. doi: 10.1165/rcmb.2013-0187OC. Am J Respir Cell Mol Biol. 2014. PMID: 24392990 Free PMC article.
Hyper-activation of pp60Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury.
Kumar S, Sun X, Noonepalle SK, Lu Q, Zemskov E, Wang T, Aggarwal S, Gross C, Sharma S, Desai AA, Hou Y, Dasarathy S, Qu N, Reddy V, Lee SG, Cherian-Shaw M, Yuan JX, Catravas JD, Rafikov R, Garcia JGN, Black SM. Kumar S, et al. Among authors: dasarathy s. Free Radic Biol Med. 2017 Jan;102:217-228. doi: 10.1016/j.freeradbiomed.2016.11.008. Epub 2016 Nov 9. Free Radic Biol Med. 2017. PMID: 27838434 Free PMC article.
PNPLA3 rs738409, age, diabetes, sex, and advanced fibrosis jointly contribute to the risk of major adverse liver outcomes in metabolic-associated steatotic liver disease.
Chalasani N, Vilar-Gomez E, Loomba R, Yates KP, Diehl AM, Neuschwander-Tetri BA, Dasarathy S, Kowdley KV, Terrault N, Wilson LA, Tonascia J, Sanyal A. Chalasani N, et al. Among authors: dasarathy s. Hepatology. 2024 Apr 23. doi: 10.1097/HEP.0000000000000896. Online ahead of print. Hepatology. 2024. PMID: 38652636
Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury.
Varadharajan V, Ramachandiran I, Massey WJ, Jain R, Banerjee R, Horak AJ, McMullen MR, Huang E, Bellar A, Lorkowski SW, Gulshan K, Helsley RN, James I, Pathak V, Dasarathy J, Welch N, Dasarathy S, Streem D, Reizes O, Allende DS, Smith JD, Simcox J, Nagy LE, Brown JM. Varadharajan V, et al. Among authors: dasarathy s. Elife. 2024 Apr 22;12:RP92243. doi: 10.7554/eLife.92243. Elife. 2024. PMID: 38648183 Free PMC article.
298 results