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A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication.
Hattori SI, Higashi-Kuwata N, Hayashi H, Allu SR, Raghavaiah J, Bulut H, Das D, Anson BJ, Lendy EK, Takamatsu Y, Takamune N, Kishimoto N, Murayama K, Hasegawa K, Li M, Davis DA, Kodama EN, Yarchoan R, Wlodawer A, Misumi S, Mesecar AD, Ghosh AK, Mitsuya H. Hattori SI, et al. Among authors: das d. Nat Commun. 2021 Jan 28;12(1):668. doi: 10.1038/s41467-021-20900-6. Nat Commun. 2021. PMID: 33510133 Free PMC article.
Structural and molecular interactions of CCR5 inhibitors with CCR5.
Maeda K, Das D, Ogata-Aoki H, Nakata H, Miyakawa T, Tojo Y, Norman R, Takaoka Y, Ding J, Arnold GF, Arnold E, Mitsuya H. Maeda K, et al. Among authors: das d. J Biol Chem. 2006 May 5;281(18):12688-98. doi: 10.1074/jbc.M512688200. Epub 2006 Feb 13. J Biol Chem. 2006. PMID: 16476734 Free article.
A novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI), GRL-98065, is potent against multiple-PI-resistant human immunodeficiency virus in vitro.
Amano M, Koh Y, Das D, Li J, Leschenko S, Wang YF, Boross PI, Weber IT, Ghosh AK, Mitsuya H. Amano M, et al. Among authors: das d. Antimicrob Agents Chemother. 2007 Jun;51(6):2143-55. doi: 10.1128/AAC.01413-06. Epub 2007 Mar 19. Antimicrob Agents Chemother. 2007. PMID: 17371811 Free PMC article.
GRL-02031, a novel nonpeptidic protease inhibitor (PI) containing a stereochemically defined fused cyclopentanyltetrahydrofuran potent against multi-PI-resistant human immunodeficiency virus type 1 in vitro.
Koh Y, Das D, Leschenko S, Nakata H, Ogata-Aoki H, Amano M, Nakayama M, Ghosh AK, Mitsuya H. Koh Y, et al. Among authors: das d. Antimicrob Agents Chemother. 2009 Mar;53(3):997-1006. doi: 10.1128/AAC.00689-08. Epub 2008 Oct 27. Antimicrob Agents Chemother. 2009. PMID: 18955518 Free PMC article.
3,863 results