Darwesh AM - Search Results

1

Cardiac Late Sodium Channel Current Is a Molecular Target for the Sodium/Glucose Cotransporter 2 Inhibitor Empagliflozin.

Philippaert K, Kalyaanamoorthy S, Fatehi M, Long W, Soni S, Byrne NJ, Barr A, Singh J, Wong J, Palechuk T, Schneider C, Darwesh AM, Maayah ZH, Seubert JM, Barakat K, Dyck JRB, Light PE. Philippaert K, et al. Among authors: darwesh am. Circulation. 2021 Jun;143(22):2188-2204. doi: 10.1161/CIRCULATIONAHA.121.053350. Epub 2021 Apr 9. Circulation. 2021. PMID: 33832341 Free PMC article.

2

Cytochrome P450-derived eicosanoids and heart function.

Jamieson KL, Endo T, Darwesh AM, Samokhvalov V, Seubert JM. Jamieson KL, et al. Among authors: darwesh am. Pharmacol Ther. 2017 Nov;179:47-83. doi: 10.1016/j.pharmthera.2017.05.005. Epub 2017 May 25. Pharmacol Ther. 2017. PMID: 28551025 Review.

3

Cytosolic carnitine acetyltransferase as a source of cytosolic acetyl-CoA: a possible mechanism for regulation of cardiac energy metabolism.

Altamimi TR, Thomas PD, Darwesh AM, Fillmore N, Mahmoud MU, Zhang L, Gupta A, Al Batran R, Seubert JM, Lopaschuk GD. Altamimi TR, et al. Among authors: darwesh am. Biochem J. 2018 Mar 9;475(5):959-976. doi: 10.1042/BCJ20170823. Biochem J. 2018. PMID: 29438065

4

DHA and 19,20-EDP induce lysosomal-proteolytic-dependent cytotoxicity through de novo ceramide production in H9c2 cells with a glycolytic profile.

Endo T, Samokhvalov V, Darwesh AM, Khey KMW, El-Sherbeni AA, Ei-Kadi AOS, Machida T, Hirafuji M, Seubert JM. Endo T, et al. Among authors: darwesh am. Cell Death Discov. 2018 Aug 20;4:29. doi: 10.1038/s41420-018-0090-1. eCollection 2018. Cell Death Discov. 2018. PMID: 30131878 Free PMC article.

5

Cardioprotective effects of CYP-derived epoxy metabolites of docosahexaenoic acid involve limiting NLRP3 inflammasome activation ¹.

Darwesh AM, Jamieson KL, Wang C, Samokhvalov V, Seubert JM. Darwesh AM, et al. Can J Physiol Pharmacol. 2019 Jun;97(6):544-556. doi: 10.1139/cjpp-2018-0480. Epub 2018 Oct 16. Can J Physiol Pharmacol. 2019. PMID: 30326194

6

Deficiency of Soluble Epoxide Hydrolase Protects Cardiac Function Impaired by LPS-Induced Acute Inflammation.

Samokhvalov V, Jamieson KL, Darwesh AM, Keshavarz-Bahaghighat H, Lee TYT, Edin M, Lih F, Zeldin DC, Seubert JM. Samokhvalov V, et al. Among authors: darwesh am. Front Pharmacol. 2019 Jan 14;9:1572. doi: 10.3389/fphar.2018.01572. eCollection 2018. Front Pharmacol. 2019. PMID: 30692927 Free PMC article.

7

Insights into the cardioprotective properties of n-3 PUFAs against ischemic heart disease via modulation of the innate immune system.

Darwesh AM, Sosnowski DK, Lee TY, Keshavarz-Bahaghighat H, Seubert JM. Darwesh AM, et al. Chem Biol Interact. 2019 Aug 1;308:20-44. doi: 10.1016/j.cbi.2019.04.037. Epub 2019 May 5. Chem Biol Interact. 2019. PMID: 31067438 Free article. Review.

8

Genetic Deletion or Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Cardiac Ischemia/Reperfusion Injury by Attenuating NLRP3 Inflammasome Activation.

Darwesh AM, Keshavarz-Bahaghighat H, Jamieson KL, Seubert JM. Darwesh AM, et al. Int J Mol Sci. 2019 Jul 17;20(14):3502. doi: 10.3390/ijms20143502. Int J Mol Sci. 2019. PMID: 31319469 Free PMC article.

9

l-Citrulline supplementation improves glucose and exercise tolerance in obese male mice.

Eshreif A, Al Batran R, Jamieson KL, Darwesh AM, Gopal K, Greenwell AA, Zlobine I, Aburasayn H, Eaton F, Mulvihill EE, Campbell JE, Seubert JM, Ussher JR. Eshreif A, et al. Among authors: darwesh am. Exp Physiol. 2020 Feb;105(2):270-281. doi: 10.1113/EP088109. Epub 2020 Jan 15. Exp Physiol. 2020. PMID: 31802553 Free article.

10

Empagliflozin Blunts Worsening Cardiac Dysfunction Associated With Reduced NLRP3 (Nucleotide-Binding Domain-Like Receptor Protein 3) Inflammasome Activation in Heart Failure.

Byrne NJ, Matsumura N, Maayah ZH, Ferdaoussi M, Takahara S, Darwesh AM, Levasseur JL, Jahng JWS, Vos D, Parajuli N, El-Kadi AOS, Braam B, Young ME, Verma S, Light PE, Sweeney G, Seubert JM, Dyck JRB. Byrne NJ, et al. Among authors: darwesh am. Circ Heart Fail. 2020 Jan;13(1):e006277. doi: 10.1161/CIRCHEARTFAILURE.119.006277. Epub 2020 Jan 20. Circ Heart Fail. 2020. PMID: 31957470

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