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Viruses traverse the human proteome through peptide interfaces that can be biomimetically leveraged for drug discovery.
Meyniel-Schicklin L, Amaudrut J, Mallinjoud P, Guillier F, Mangeot PE, Lines L, Aublin-Gex A, Scholtes C, Punginelli C, Joly S, Vasseur F, Manet E, Gruffat H, Henry T, Halitim F, Paparin JL, Machin P, Darteil R, Sampson D, Mikaelian I, Lane L, Navratil V, Golinelli-Cohen MP, Terzi F, André P, Lotteau V, Vonderscher J, Meldrum EC, de Chassey B. Meyniel-Schicklin L, et al. Among authors: darteil r. Proc Natl Acad Sci U S A. 2024 Jan 30;121(5):e2308776121. doi: 10.1073/pnas.2308776121. Epub 2024 Jan 22. Proc Natl Acad Sci U S A. 2024. PMID: 38252831 Free PMC article.
Hepatic and renal improvements with FXR agonist vonafexor in individuals with suspected fibrotic NASH.
Ratziu V, Harrison SA, Loustaud-Ratti V, Bureau C, Lawitz E, Abdelmalek M, Alkhouri N, Francque S, Girma H, Darteil R, Couchoux H, Wolf M, Sanyal A, Vonderscher J, Scalfaro P. Ratziu V, et al. Among authors: darteil r. J Hepatol. 2023 Mar;78(3):479-492. doi: 10.1016/j.jhep.2022.10.023. Epub 2022 Nov 9. J Hepatol. 2023. PMID: 36334688 Free article. Clinical Trial.
Farnesoid X receptor agonist for the treatment of chronic hepatitis B: A safety study.
Erken R, Andre P, Roy E, Kootstra N, Barzic N, Girma H, Laveille C, Radreau-Pierini P, Darteil R, Vonderscher J, Scalfaro P, Tangkijvanich P, Flisiak R, Reesink H. Erken R, et al. Among authors: darteil r. J Viral Hepat. 2021 Dec;28(12):1690-1698. doi: 10.1111/jvh.13608. Epub 2021 Sep 29. J Viral Hepat. 2021. PMID: 34467593 Free PMC article. Clinical Trial.
A blood-based biomarker panel (NIS4) for non-invasive diagnosis of non-alcoholic steatohepatitis and liver fibrosis: a prospective derivation and global validation study.
Harrison SA, Ratziu V, Boursier J, Francque S, Bedossa P, Majd Z, Cordonnier G, Sudrik FB, Darteil R, Liebe R, Magnanensi J, Hajji Y, Brozek J, Roudot A, Staels B, Hum DW, Megnien SJ, Hosmane S, Dam N, Chaumat P, Hanf R, Anstee QM, Sanyal AJ. Harrison SA, et al. Among authors: darteil r. Lancet Gastroenterol Hepatol. 2020 Nov;5(11):970-985. doi: 10.1016/S2468-1253(20)30252-1. Epub 2020 Aug 5. Lancet Gastroenterol Hepatol. 2020. PMID: 32763196 Clinical Trial.
Farnesoid X receptor represses hepatic lipase gene expression.
Sirvent A, Verhoeven AJ, Jansen H, Kosykh V, Darteil RJ, Hum DW, Fruchart JC, Staels B. Sirvent A, et al. Among authors: darteil rj. J Lipid Res. 2004 Nov;45(11):2110-5. doi: 10.1194/jlr.M400221-JLR200. Epub 2004 Sep 1. J Lipid Res. 2004. PMID: 15342685 Free article.
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