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Omecamtiv mecarbil does not prolong QTc intervals at therapeutic concentrations.
Trivedi A, Hsu CP, Jafarinasabian P, Terminello B, Zhang H, Flach S, Israel S, Brooks A, Xue H, Darpo B, Abbasi S, Dutta S, Lee E. Trivedi A, et al. Among authors: darpo b. Br J Clin Pharmacol. 2022 Jan;88(1):187-198. doi: 10.1111/bcp.14939. Epub 2021 Jul 16. Br J Clin Pharmacol. 2022. PMID: 34131942 Free article. Clinical Trial.
Evaluating Potential QT Effects of JNJ-54861911, a BACE Inhibitor in Single- and Multiple-Ascending Dose Studies, and a Thorough QT Trial With Additional Retrospective Confirmation, Using Concentration-QTc Analysis.
Timmers M, Sinha V, Darpo B, Smith B, Brown R, Xue H, Ferber G, Streffer J, Russu A, Tritsmans L, Solanki B, Bogert J, Van Nueten L, Salvadore G, Nandy P. Timmers M, et al. Among authors: darpo b. J Clin Pharmacol. 2018 Jul;58(7):952-964. doi: 10.1002/jcph.1087. Epub 2018 Mar 5. J Clin Pharmacol. 2018. PMID: 29505101 Clinical Trial.
Safety, Pharmacokinetics, and Pharmacodynamics of Trazpiroben (TAK-906), a Novel Selective D2 /D3 Receptor Antagonist: A Phase 1 Randomized, Placebo-Controlled Single- and Multiple-Dose Escalation Study in Healthy Participants.
Whiting RL, Darpo B, Chen C, Fletcher M, Combs D, Xue H, Stoltz RR. Whiting RL, et al. Among authors: darpo b. Clin Pharmacol Drug Dev. 2021 Aug;10(8):927-939. doi: 10.1002/cpdd.906. Epub 2021 Jan 18. Clin Pharmacol Drug Dev. 2021. PMID: 33462988 Free PMC article. Clinical Trial.
127 results