Darnell JC - Search Results

1

Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome.

Seo SS, Louros SR, Anstey N, Gonzalez-Lozano MA, Harper CB, Verity NC, Dando O, Thomson SR, Darnell JC, Kind PC, Li KW, Osterweil EK. Seo SS, et al. Among authors: darnell jc. Nat Commun. 2022 Jun 10;13(1):3236. doi: 10.1038/s41467-022-30979-0. Nat Commun. 2022. PMID: 35688821 Free PMC article.

2

The translation of translational control by FMRP: therapeutic targets for FXS.

Darnell JC, Klann E. Darnell JC, et al. Nat Neurosci. 2013 Nov;16(11):1530-6. doi: 10.1038/nn.3379. Epub 2013 Apr 14. Nat Neurosci. 2013. PMID: 23584741 Free PMC article. Review.

3

A mouse model of the human Fragile X syndrome I304N mutation.

Zang JB, Nosyreva ED, Spencer CM, Volk LJ, Musunuru K, Zhong R, Stone EF, Yuva-Paylor LA, Huber KM, Paylor R, Darnell JC, Darnell RB. Zang JB, et al. Among authors: darnell jc, darnell rb. PLoS Genet. 2009 Dec;5(12):e1000758. doi: 10.1371/journal.pgen.1000758. Epub 2009 Dec 11. PLoS Genet. 2009. PMID: 20011099 Free PMC article.

4

FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism.

Darnell JC, Van Driesche SJ, Zhang C, Hung KY, Mele A, Fraser CE, Stone EF, Chen C, Fak JJ, Chi SW, Licatalosi DD, Richter JD, Darnell RB. Darnell JC, et al. Among authors: darnell rb. Cell. 2011 Jul 22;146(2):247-61. doi: 10.1016/j.cell.2011.06.013. Cell. 2011. PMID: 21784246 Free PMC article.

5

Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells.

Stefani G, Fraser CE, Darnell JC, Darnell RB. Stefani G, et al. Among authors: darnell jc, darnell rb. J Neurosci. 2004 Aug 18;24(33):7272-6. doi: 10.1523/JNEUROSCI.2306-04.2004. J Neurosci. 2004. PMID: 15317853 Free PMC article.

6

FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory.

Sawicka K, Hale CR, Park CY, Fak JJ, Gresack JE, Van Driesche SJ, Kang JJ, Darnell JC, Darnell RB. Sawicka K, et al. Among authors: darnell jc. Elife. 2019 Dec 20;8:e46919. doi: 10.7554/eLife.46919. Elife. 2019. PMID: 31860442 Free PMC article.

7

Cholesterol levels in fragile X syndrome.

Berry-Kravis E, Levin R, Shah H, Mathur S, Darnell JC, Ouyang B. Berry-Kravis E, et al. Among authors: darnell jc. Am J Med Genet A. 2015 Feb;167A(2):379-84. doi: 10.1002/ajmg.a.36850. Epub 2014 Nov 25. Am J Med Genet A. 2015. PMID: 25424470 Free PMC article.

8

The fragile X mental retardation protein, FMRP, recognizes G-quartets.

Darnell JC, Warren ST, Darnell RB. Darnell JC, et al. Among authors: darnell rb. Ment Retard Dev Disabil Res Rev. 2004;10(1):49-52. doi: 10.1002/mrdd.20008. Ment Retard Dev Disabil Res Rev. 2004. PMID: 14994288 Review.

9

Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function.

Darnell JC, Jensen KB, Jin P, Brown V, Warren ST, Darnell RB. Darnell JC, et al. Among authors: darnell rb. Cell. 2001 Nov 16;107(4):489-99. doi: 10.1016/s0092-8674(01)00566-9. Cell. 2001. PMID: 11719189 Free article.

10

Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs.

Darnell JC, Fraser CE, Mostovetsky O, Darnell RB. Darnell JC, et al. Among authors: darnell rb. Hum Mol Genet. 2009 Sep 1;18(17):3164-77. doi: 10.1093/hmg/ddp255. Epub 2009 Jun 1. Hum Mol Genet. 2009. PMID: 19487368 Free PMC article.

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