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CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity.
House IG, Derrick EB, Sek K, Chen AXY, Li J, Lai J, Todd KL, Munoz I, Michie J, Chan CW, Huang YK, Chan JD, Petley EV, Tong J, Nguyen D, Engel S, Savas P, Hogg SJ, Vervoort SJ, Kearney CJ, Burr ML, Lam EYN, Gilan O, Bedoui S, Johnstone RW, Dawson MA, Loi S, Darcy PK, Beavis PA. House IG, et al. Among authors: darcy pk. Cell Rep. 2023 Aug 29;42(8):113014. doi: 10.1016/j.celrep.2023.113014. Epub 2023 Aug 21. Cell Rep. 2023. PMID: 37605534 Free article.
CD73-deficient mice are resistant to carcinogenesis.
Stagg J, Beavis PA, Divisekera U, Liu MC, Möller A, Darcy PK, Smyth MJ. Stagg J, et al. Among authors: darcy pk. Cancer Res. 2012 May 1;72(9):2190-6. doi: 10.1158/0008-5472.CAN-12-0420. Epub 2012 Mar 6. Cancer Res. 2012. PMID: 22396496
CD73: a potent suppressor of antitumor immune responses.
Beavis PA, Stagg J, Darcy PK, Smyth MJ. Beavis PA, et al. Among authors: darcy pk. Trends Immunol. 2012 May;33(5):231-7. doi: 10.1016/j.it.2012.02.009. Epub 2012 Apr 7. Trends Immunol. 2012. PMID: 22487321 Review.
Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors.
Beavis PA, Divisekera U, Paget C, Chow MT, John LB, Devaud C, Dwyer K, Stagg J, Smyth MJ, Darcy PK. Beavis PA, et al. Among authors: darcy pk. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14711-6. doi: 10.1073/pnas.1308209110. Epub 2013 Aug 20. Proc Natl Acad Sci U S A. 2013. PMID: 23964122 Free PMC article.
A2A blockade enhances anti-metastatic immune responses.
Beavis PA, Milenkovski N, Stagg J, Smyth MJ, Darcy PK. Beavis PA, et al. Among authors: darcy pk. Oncoimmunology. 2013 Dec 1;2(12):e26705. doi: 10.4161/onci.26705. Epub 2013 Oct 22. Oncoimmunology. 2013. PMID: 24575377 Free PMC article.
201 results