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Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.
Nat Commun. 2020 Oct 23;11(1):5370. doi: 10.1038/s41467-020-19227-5.
Nat Commun. 2020.
PMID: 33097708
Free PMC article.
The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model.
Claes C, England WE, Danhash EP, Kiani Shabestari S, Jairaman A, Chadarevian JP, Hasselmann J, Tsai AP, Coburn MA, Sanchez J, Lim TE, Hidalgo JLS, Tu C, Cahalan MD, Lamb BT, Landreth GE, Spitale RC, Blurton-Jones M, Davtyan H.
Claes C, et al. Among authors: danhash ep.
Alzheimers Dement. 2022 Oct;18(10):1765-1778. doi: 10.1002/alz.12577. Epub 2022 Feb 9.
Alzheimers Dement. 2022.
PMID: 35142046
Free PMC article.
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Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer's disease.
Claes C, Danhash EP, Hasselmann J, Chadarevian JP, Shabestari SK, England WE, Lim TE, Hidalgo JLS, Spitale RC, Davtyan H, Blurton-Jones M.
Claes C, et al. Among authors: danhash ep.
Mol Neurodegener. 2021 Jul 23;16(1):50. doi: 10.1186/s13024-021-00473-0.
Mol Neurodegener. 2021.
PMID: 34301296
Free PMC article.
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Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice.
Kiani Shabestari S, Morabito S, Danhash EP, McQuade A, Sanchez JR, Miyoshi E, Chadarevian JP, Claes C, Coburn MA, Hasselmann J, Hidalgo J, Tran KN, Martini AC, Chang Rothermich W, Pascual J, Head E, Hume DA, Pridans C, Davtyan H, Swarup V, Blurton-Jones M.
Kiani Shabestari S, et al. Among authors: danhash ep.
Cell Rep. 2022 Jun 14;39(11):110961. doi: 10.1016/j.celrep.2022.110961.
Cell Rep. 2022.
PMID: 35705056
Free PMC article.
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Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice.
Davtyan H, Hovakimyan A, Kiani Shabestari S, Antonyan T, Coburn MA, Zagorski K, Chailyan G, Petrushina I, Svystun O, Danhash E, Petrovsky N, Cribbs DH, Agadjanyan MG, Blurton-Jones M, Ghochikyan A.
Davtyan H, et al. Among authors: danhash e.
Alzheimers Res Ther. 2019 Dec 17;11(1):107. doi: 10.1186/s13195-019-0556-2.
Alzheimers Res Ther. 2019.
PMID: 31847886
Free PMC article.
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Amyloid-beta impairs TOM1-mediated IL-1R1 signaling.
Martini AC, Gomez-Arboledas A, Forner S, Rodriguez-Ortiz CJ, McQuade A, Danhash E, Phan J, Javonillo D, Ha JV, Tram M, Trujillo-Estrada L, da Cunha C, Ager RR, Davila JC, Kitazawa M, Blurton-Jones M, Gutierrez A, Baglietto-Vargas D, Medeiros R, LaFerla FM.
Martini AC, et al. Among authors: danhash e.
Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21198-21206. doi: 10.1073/pnas.1914088116. Epub 2019 Sep 30.
Proc Natl Acad Sci U S A. 2019.
PMID: 31570577
Free PMC article.
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The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C.
Pluvinage JV, Sun J, Claes C, Flynn RA, Haney MS, Iram T, Meng X, Lindemann R, Riley NM, Danhash E, Chadarevian JP, Tapp E, Gate D, Kondapavulur S, Cobos I, Chetty S, Pașca AM, Pașca SP, Berry-Kravis E, Bertozzi CR, Blurton-Jones M, Wyss-Coray T.
Pluvinage JV, et al. Among authors: danhash e.
Sci Transl Med. 2021 Dec;13(622):eabg2919. doi: 10.1126/scitranslmed.abg2919. Epub 2021 Dec 1.
Sci Transl Med. 2021.
PMID: 34851695
Free PMC article.
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Author Correction: Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.
McQuade A, Kang YJ, Hasselmann J, Jairaman A, Sotelo A, Coburn M, Shabestari SK, Chadarevian JP, Fote G, Tu CH, Danhash E, Silva J, Martinez E, Cotman C, Prieto GA, Thompson LM, Steffan JS, Smith I, Davtyan H, Cahalan M, Cho H, Blurton-Jones M.
McQuade A, et al. Among authors: danhash e.
Nat Commun. 2023 Mar 2;14(1):1194. doi: 10.1038/s41467-023-36930-1.
Nat Commun. 2023.
PMID: 36864071
Free PMC article.
No abstract available.
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