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2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms.
Freund I, Buhl DK, Boutin S, Kotter A, Pichot F, Marchand V, Vierbuchen T, Heine H, Motorin Y, Helm M, Dalpke AH, Eigenbrod T. Freund I, et al. Among authors: dalpke ah. RNA. 2019 Jul;25(7):869-880. doi: 10.1261/rna.070243.118. Epub 2019 Apr 24. RNA. 2019. PMID: 31019095 Free PMC article.
DAMP signaling is a key pathway inducing immune modulation after brain injury.
Liesz A, Dalpke A, Mracsko E, Antoine DJ, Roth S, Zhou W, Yang H, Na SY, Akhisaroglu M, Fleming T, Eigenbrod T, Nawroth PP, Tracey KJ, Veltkamp R. Liesz A, et al. J Neurosci. 2015 Jan 14;35(2):583-98. doi: 10.1523/JNEUROSCI.2439-14.2015. J Neurosci. 2015. PMID: 25589753 Free PMC article.
184 results