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Inhibition of the extracellular enzyme A disintegrin and metalloprotease with thrombospondin motif 4 prevents cardiac fibrosis and dysfunction.
Vistnes M, Erusappan PM, Sasi A, Nordén ES, Bergo KK, Romaine A, Lunde IG, Zhang L, Olsen MB, Øgaard J, Carlson CR, Wang CH, Riise J, Dahl CP, Fiane AE, Hauge-Iversen IM, Espe E, Melleby AO, Tønnessen T, Aronsen JM, Sjaastad I, Christensen G. Vistnes M, et al. Among authors: dahl cp. Cardiovasc Res. 2023 Aug 19;119(10):1915-1927. doi: 10.1093/cvr/cvad078. Cardiovasc Res. 2023. PMID: 37216909 Free PMC article.
Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload.
Waehre A, Halvorsen B, Yndestad A, Husberg C, Sjaastad I, Nygård S, Dahl CP, Ahmed MS, Finsen AV, Reims H, Louch WE, Hilfiker-Kleiner D, Vinge LE, Roald B, Attramadal H, Lipp M, Gullestad L, Aukrust P, Christensen G. Waehre A, et al. Among authors: dahl cp. PLoS One. 2011 Apr 18;6(4):e18668. doi: 10.1371/journal.pone.0018668. PLoS One. 2011. PMID: 21533157 Free PMC article.
The homeostatic chemokine CCL21 predicts mortality and may play a pathogenic role in heart failure.
Yndestad A, Finsen AV, Ueland T, Husberg C, Dahl CP, Øie E, Vinge LE, Sjaastad I, Sandanger Ø, Ranheim T, Dickstein K, Kjekshus J, Damås JK, Fiane AE, Hilfiker-Kleiner D, Lipp M, Gullestad L, Christensen G, Aukrust P. Yndestad A, et al. Among authors: dahl cp. PLoS One. 2012;7(3):e33038. doi: 10.1371/journal.pone.0033038. Epub 2012 Mar 12. PLoS One. 2012. PMID: 22427939 Free PMC article.
Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart.
Strand ME, Herum KM, Rana ZA, Skrbic B, Askevold ET, Dahl CP, Vistnes M, Hasic A, Kvaløy H, Sjaastad I, Carlson CR, Tønnessen T, Gullestad L, Christensen G, Lunde IG. Strand ME, et al. Among authors: dahl cp. FEBS J. 2013 May;280(10):2228-47. doi: 10.1111/febs.12161. Epub 2013 Feb 24. FEBS J. 2013. PMID: 23374111 Free article.
Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli.
Engebretsen KV, Lunde IG, Strand ME, Waehre A, Sjaastad I, Marstein HS, Skrbic B, Dahl CP, Askevold ET, Christensen G, Bjørnstad JL, Tønnessen T. Engebretsen KV, et al. Among authors: dahl cp. FEBS J. 2013 May;280(10):2382-98. doi: 10.1111/febs.12235. Epub 2013 Apr 2. FEBS J. 2013. PMID: 23480731 Free article.
The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.
Sandanger Ø, Ranheim T, Vinge LE, Bliksøen M, Alfsnes K, Finsen AV, Dahl CP, Askevold ET, Florholmen G, Christensen G, Fitzgerald KA, Lien E, Valen G, Espevik T, Aukrust P, Yndestad A. Sandanger Ø, et al. Among authors: dahl cp. Cardiovasc Res. 2013 Jul 1;99(1):164-74. doi: 10.1093/cvr/cvt091. Epub 2013 Apr 10. Cardiovasc Res. 2013. PMID: 23580606
71 results