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Performance of plasma phosphorylated tau 181 and 217 in the community.
Mielke MM, Dage JL, Frank RD, Algeciras-Schimnich A, Knopman DS, Lowe VJ, Bu G, Vemuri P, Graff-Radford J, Jack CR Jr, Petersen RC. Mielke MM, et al. Among authors: dage jl. Nat Med. 2022 Jul;28(7):1398-1405. doi: 10.1038/s41591-022-01822-2. Epub 2022 May 26. Nat Med. 2022. PMID: 35618838 Free PMC article.
Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography.
Mielke MM, Hagen CE, Xu J, Chai X, Vemuri P, Lowe VJ, Airey DC, Knopman DS, Roberts RO, Machulda MM, Jack CR Jr, Petersen RC, Dage JL. Mielke MM, et al. Among authors: dage jl. Alzheimers Dement. 2018 Aug;14(8):989-997. doi: 10.1016/j.jalz.2018.02.013. Epub 2018 Apr 5. Alzheimers Dement. 2018. PMID: 29626426 Free PMC article.
Plasma P-tau181 in Alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia.
Janelidze S, Mattsson N, Palmqvist S, Smith R, Beach TG, Serrano GE, Chai X, Proctor NK, Eichenlaub U, Zetterberg H, Blennow K, Reiman EM, Stomrud E, Dage JL, Hansson O. Janelidze S, et al. Among authors: dage jl. Nat Med. 2020 Mar;26(3):379-386. doi: 10.1038/s41591-020-0755-1. Epub 2020 Mar 2. Nat Med. 2020. PMID: 32123385
Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration.
Thijssen EH, La Joie R, Wolf A, Strom A, Wang P, Iaccarino L, Bourakova V, Cobigo Y, Heuer H, Spina S, VandeVrede L, Chai X, Proctor NK, Airey DC, Shcherbinin S, Duggan Evans C, Sims JR, Zetterberg H, Blennow K, Karydas AM, Teunissen CE, Kramer JH, Grinberg LT, Seeley WW, Rosen H, Boeve BF, Miller BL, Rabinovici GD, Dage JL, Rojas JC, Boxer AL; Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) investigators. Thijssen EH, et al. Among authors: dage jl. Nat Med. 2020 Mar;26(3):387-397. doi: 10.1038/s41591-020-0762-2. Epub 2020 Mar 2. Nat Med. 2020. PMID: 32123386 Free PMC article.
Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer's disease.
Janelidze S, Stomrud E, Smith R, Palmqvist S, Mattsson N, Airey DC, Proctor NK, Chai X, Shcherbinin S, Sims JR, Triana-Baltzer G, Theunis C, Slemmon R, Mercken M, Kolb H, Dage JL, Hansson O. Janelidze S, et al. Among authors: dage jl. Nat Commun. 2020 Apr 3;11(1):1683. doi: 10.1038/s41467-020-15436-0. Nat Commun. 2020. PMID: 32246036 Free PMC article.
Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer's disease.
Mattsson-Carlgren N, Andersson E, Janelidze S, Ossenkoppele R, Insel P, Strandberg O, Zetterberg H, Rosen HJ, Rabinovici G, Chai X, Blennow K, Dage JL, Stomrud E, Smith R, Palmqvist S, Hansson O. Mattsson-Carlgren N, et al. Among authors: dage jl. Sci Adv. 2020 Apr 15;6(16):eaaz2387. doi: 10.1126/sciadv.aaz2387. eCollection 2020 Apr. Sci Adv. 2020. PMID: 32426454 Free PMC article.
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