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Overcoming target epitope masking resistance that can occur on low-antigen-expresser AML blasts after IL-1RAP chimeric antigen receptor T cell therapy using the inducible caspase 9 suicide gene safety switch.
Warda W, Da Rocha MN, Trad R, Haderbache R, Salma Y, Bouquet L, Roussel X, Nicod C, Deschamps M, Ferrand C. Warda W, et al. Among authors: da rocha mn. Cancer Gene Ther. 2021 Dec;28(12):1365-1375. doi: 10.1038/s41417-020-00284-3. Epub 2021 Jan 7. Cancer Gene Ther. 2021. PMID: 33414517 Free PMC article.
Droplet digital PCR allows vector copy number assessment and monitoring of experimental CAR T cells in murine xenograft models or approved CD19 CAR T cell-treated patients.
Haderbache R, Warda W, Hervouet E, da Rocha MN, Trad R, Allain V, Nicod C, Thieblemeont C, Boissel N, Varlet P, Agha IY, Bouquet L, Guiot M, Venet F, Sujobert P, Roussel X, Rouzaire PO, Caillot D, Casasnovas O, Bories JC, Bachy E, Caillat-Zucman S, Deschamps M, Ferrand C. Haderbache R, et al. Among authors: da rocha mn. J Transl Med. 2021 Jun 21;19(1):265. doi: 10.1186/s12967-021-02925-z. J Transl Med. 2021. PMID: 34154602 Free PMC article.
CAR-T cells targeting IL-1RAP produced in a closed semiautomatic system are ready for the first phase I clinical investigation in humans.
Nicod C, da Rocha MN, Warda W, Roussel X, Haderbache R, Seffar E, Trad R, Bouquet L, Goncalves M, Bosdure L, Laude MC, Guiot M, Ferrand C, Deschamps M. Nicod C, et al. Among authors: da rocha mn. Curr Res Transl Med. 2023 Apr-Jun;71(2):103385. doi: 10.1016/j.retram.2023.103385. Epub 2023 Feb 4. Curr Res Transl Med. 2023. PMID: 36773434 Free article.
Insights of potential trypanocidal effect of the synthetic derivative (2E)-1-(4-aminophenyl)-3-(2,4-dichlorophenyl)prop-2-en-1-one: in vitro assay, MEV analysis, quantum study, molecular docking, molecular dynamics, MPO analysis, and predictive ADMET.
Marinho MM, da Rocha MN, Magalhães EP, Ribeiro LR, Roberto CHA, de Queiroz Almeida-Neto FW, Monteiro ML, Nunes JVS, de Menezes RRPPB, Marinho ES, de Lima Neto P, Martins AMC, Dos Santos HS. Marinho MM, et al. Among authors: da rocha mn. Naunyn Schmiedebergs Arch Pharmacol. 2024 May 9. doi: 10.1007/s00210-024-03138-z. Online ahead of print. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 38722342
Heterocyclic chalcone (E)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-(thiophen-2-yl) prop-2-en-1-one derived from a natural product with antinociceptive, anti-inflammatory, and hypoglycemic effect in adult zebrafish.
Ferreira MKA, Freitas WPO, Barbosa IM, da Rocha MN, da Silva AW, de Lima Rebouças E, da Silva Mendes FR, Alves CR, Nunes PIG, Marinho MM, Furtado RF, Santos FA, Marinho ES, de Menezes JESA, Dos Santos HS. Ferreira MKA, et al. Among authors: da rocha mn. 3 Biotech. 2023 Aug;13(8):276. doi: 10.1007/s13205-023-03696-8. Epub 2023 Jul 14. 3 Biotech. 2023. PMID: 37457871
GABAA and serotonergic receptors participation in anxiolytic effect of chalcones in adult zebrafish.
Mendes FRS, da Silva AW, Ferreira MKA, Rebouças EL, Moura Barbosa I, da Rocha MN, Henrique Ferreira Ribeiro W, Menezes RRPPB, Magalhães EP, Marinho EM, Marinho MM, Bandeira PN, de Menezes JESA, Marinho ES, Dos Santos HS. Mendes FRS, et al. Among authors: da rocha mn. J Biomol Struct Dyn. 2023;41(21):12426-12444. doi: 10.1080/07391102.2023.2167116. Epub 2023 Jan 16. J Biomol Struct Dyn. 2023. PMID: 36644862
16 results