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Page 1
The BRD4-NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma.
Durall RT, Huang J, Wojenski L, Huang Y, Gokhale PC, Leeper BA, Nash JO, Ballester PL, Davidson S, Shlien A, Sotirakis E, Bertaux F, Dubus V, Luo J, Wu CJ, Keskin DB, Eagen KP, Shapiro GI, French CA. Durall RT, et al. Cancer Res. 2023 Dec 1;83(23):3846-3860. doi: 10.1158/0008-5472.CAN-23-2545. Cancer Res. 2023. PMID: 37819236 Free PMC article.
EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes.
Huang Y, Durall RT, Luong NM, Hertzler HJ, Huang J, Gokhale PC, Leeper BA, Persky NS, Root DE, Anekal PV, Montero Llopis PDLM, David CN, Kutok JL, Raimondi A, Saluja K, Luo J, Zahnow CA, Adane B, Stegmaier K, Hawkins CE, Ponne C, Le Q, Shapiro GI, Lemieux ME, Eagen KP, French CA. Huang Y, et al. Cancer Res. 2023 Dec 1;83(23):3956-3973. doi: 10.1158/0008-5472.CAN-23-1475. Cancer Res. 2023. PMID: 37747726
EZH2 synergizes with BRD4-NUT to drive NUT carcinoma growth through silencing of key tumor suppressor genes.
Huang Y, Durall RT, Luong NM, Hertzler HJ, Huang J, Gokhale PC, Leeper BA, Persky NS, Root DE, Anekal PV, Montero Llopis PDLM, David CN, Kutok JL, Raimondi A, Saluja K, Luo J, Zahnow CA, Adane B, Stegmaier K, Hawkins CE, Ponne C, Le Q, Shapiro GI, Lemieux ME, Eagen KP, French CA. Huang Y, et al. bioRxiv [Preprint]. 2023 Aug 16:2023.08.15.553204. doi: 10.1101/2023.08.15.553204. bioRxiv. 2023. PMID: 37645799 Free PMC article. Updated. Preprint.
UBR7 acts as a histone chaperone for post-nucleosomal histone H3.
Hogan AK, Sathyan KM, Willis AB, Khurana S, Srivastava S, Zasadzińska E, Lee AS, Bailey AO, Gaynes MN, Huang J, Bodner J, Rosencrance CD, Wong KA, Morgan MA, Eagen KP, Shilatifard A, Foltz DR. Hogan AK, et al. EMBO J. 2021 Dec 15;40(24):e108307. doi: 10.15252/embj.2021108307. Epub 2021 Nov 17. EMBO J. 2021. PMID: 34786730 Free PMC article.
Supercharging BRD4 with NUT in carcinoma.
Eagen KP, French CA. Eagen KP, et al. Oncogene. 2021 Feb;40(8):1396-1408. doi: 10.1038/s41388-020-01625-0. Epub 2021 Jan 15. Oncogene. 2021. PMID: 33452461 Free PMC article. Review.
Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation.
Fang C, Wang Z, Han C, Safgren SL, Helmin KA, Adelman ER, Serafin V, Basso G, Eagen KP, Gaspar-Maia A, Figueroa ME, Singer BD, Ratan A, Ntziachristos P, Zang C. Fang C, et al. Genome Biol. 2020 Sep 15;21(1):247. doi: 10.1186/s13059-020-02152-7. Genome Biol. 2020. PMID: 32933554 Free PMC article.
Contact Mapping to Unravel Chromosome Folding.
Ge T, Rosencrance CD, Eagen KP. Ge T, et al. Trends Biochem Sci. 2019 Dec;44(12):1089-1090. doi: 10.1016/j.tibs.2019.09.006. Epub 2019 Oct 31. Trends Biochem Sci. 2019. PMID: 31677956 Free PMC article. No abstract available.