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Cholecystokinin expression in the β-cell leads to increased β-cell area in aged mice and protects from streptozotocin-induced diabetes and apoptosis.
Lavine JA, Kibbe CR, Baan M, Sirinvaravong S, Umhoefer HM, Engler KA, Meske LM, Sacotte KA, Erhardt DP, Davis DB. Lavine JA, et al. Am J Physiol Endocrinol Metab. 2015 Nov 15;309(10):E819-28. doi: 10.1152/ajpendo.00159.2015. Epub 2015 Sep 22. Am J Physiol Endocrinol Metab. 2015. PMID: 26394663 Free PMC article.
Pancreatic β-cell proliferation in obesity.
Linnemann AK, Baan M, Davis DB. Linnemann AK, et al. Adv Nutr. 2014 May 14;5(3):278-88. doi: 10.3945/an.113.005488. Print 2014 May. Adv Nutr. 2014. PMID: 24829474 Free PMC article. Review.
FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation.
Davis DB, Lavine JA, Suhonen JI, Krautkramer KA, Rabaglia ME, Sperger JM, Fernandez LA, Yandell BS, Keller MP, Wang IM, Schadt EE, Attie AD. Davis DB, et al. Mol Endocrinol. 2010 Sep;24(9):1822-34. doi: 10.1210/me.2010-0082. Epub 2010 Jul 21. Mol Endocrinol. 2010. PMID: 20660304 Free PMC article.