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Commensal Bacterium Rothia aeria Degrades and Detoxifies Gluten via a Highly Effective Subtilisin Enzyme.
Wei G, Darwish G, Oppenheim FG, Schuppan D, Helmerhorst EJ. Wei G, et al. Nutrients. 2020 Dec 2;12(12):3724. doi: 10.3390/nu12123724. Nutrients. 2020. PMID: 33276655 Free PMC article.
Celiac disease is characterized by a chronic immune-mediated inflammation of the small intestine, triggered by gluten contained in wheat, barley, and rye. Rothia aeria, a gram-positive natural colonizer of the oral cavity and the upper digestive tract is able to degrade an …
Celiac disease is characterized by a chronic immune-mediated inflammation of the small intestine, triggered by gluten contained in wheat …
Gluten Degrading Enzymes for Treatment of Celiac Disease.
Wei G, Helmerhorst EJ, Darwish G, Blumenkranz G, Schuppan D. Wei G, et al. Nutrients. 2020 Jul 15;12(7):2095. doi: 10.3390/nu12072095. Nutrients. 2020. PMID: 32679754 Free PMC article. Review.
CeD is triggered and maintained by the ingestion of gluten proteins from wheat and related grains. Gluten peptides that resist gastrointestinal digestion are antigenically presented to gluten specific T cells in the intestinal mucosa via HLA-DQ2 or HLA-DQ8, t …
CeD is triggered and maintained by the ingestion of gluten proteins from wheat and related grains. Gluten peptides that resist gas …