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The metalloproteinase ADAM10 requires its activity to sustain surface expression.
Seifert A, Düsterhöft S, Wozniak J, Koo CZ, Tomlinson MG, Nuti E, Rossello A, Cuffaro D, Yildiz D, Ludwig A. Seifert A, et al. Among authors: dusterhoft s. Cell Mol Life Sci. 2021 Jan;78(2):715-732. doi: 10.1007/s00018-020-03507-w. Epub 2020 May 5. Cell Mol Life Sci. 2021. PMID: 32372373 Free PMC article.
Status update on iRhom and ADAM17: It's still complicated.
Düsterhöft S, Babendreyer A, Giese AA, Flasshove C, Ludwig A. Düsterhöft S, et al. Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1567-1583. doi: 10.1016/j.bbamcr.2019.06.017. Epub 2019 Jul 19. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 31330158 Free article. Review.
Differential Induction of the ADAM17 Regulators iRhom1 and 2 in Endothelial Cells.
Babendreyer A, Rojas-González DM, Giese AA, Fellendorf S, Düsterhöft S, Mela P, Ludwig A. Babendreyer A, et al. Among authors: dusterhoft s. Front Cardiovasc Med. 2020 Dec 1;7:610344. doi: 10.3389/fcvm.2020.610344. eCollection 2020. Front Cardiovasc Med. 2020. PMID: 33335915 Free PMC article.
A structural model of the iRhom-ADAM17 sheddase complex reveals functional insights into its trafficking and activity.
Kahveci-Türköz S, Bläsius K, Wozniak J, Rinkens C, Seifert A, Kasparek P, Ohm H, Oltzen S, Nieszporek M, Schwarz N, Babendreyer A, Preisinger C, Sedlacek R, Ludwig A, Düsterhöft S. Kahveci-Türköz S, et al. Among authors: dusterhoft s. Cell Mol Life Sci. 2023 Apr 29;80(5):135. doi: 10.1007/s00018-023-04783-y. Cell Mol Life Sci. 2023. PMID: 37119365 Free PMC article.
46 results