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Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation.
Gruijs da Silva LA, Simonetti F, Hutten S, Riemenschneider H, Sternburg EL, Pietrek LM, Gebel J, Dötsch V, Edbauer D, Hummer G, Stelzl LS, Dormann D. Gruijs da Silva LA, et al. Among authors: dotsch v. EMBO J. 2022 Apr 19;41(8):e108443. doi: 10.15252/embj.2021108443. Epub 2022 Feb 3. EMBO J. 2022. PMID: 35112738 Free PMC article.
Analysis of the oligomeric state and transactivation potential of TAp73α.
Luh LM, Kehrloesser S, Deutsch GB, Gebel J, Coutandin D, Schäfer B, Agostini M, Melino G, Dötsch V. Luh LM, et al. Among authors: dotsch v. Cell Death Differ. 2013 Aug;20(8):1008-16. doi: 10.1038/cdd.2013.23. Epub 2013 Mar 29. Cell Death Differ. 2013. PMID: 23538419 Free PMC article.
Control mechanisms in germ cells mediated by p53 family proteins.
Gebel J, Tuppi M, Krauskopf K, Coutandin D, Pitzius S, Kehrloesser S, Osterburg C, Dötsch V. Gebel J, et al. Among authors: dotsch v. J Cell Sci. 2017 Aug 9:jcs.204859. doi: 10.1242/jcs.204859. Online ahead of print. J Cell Sci. 2017. PMID: 28794013 Review.
Non-oncogenic roles of TAp73: from multiciliogenesis to metabolism.
Nemajerova A, Amelio I, Gebel J, Dötsch V, Melino G, Moll UM. Nemajerova A, et al. Among authors: dotsch v. Cell Death Differ. 2018 Jan;25(1):144-153. doi: 10.1038/cdd.2017.178. Epub 2017 Oct 27. Cell Death Differ. 2018. PMID: 29077094 Free PMC article. Review.
p63 uses a switch-like mechanism to set the threshold for induction of apoptosis.
Gebel J, Tuppi M, Chaikuad A, Hötte K, Schröder M, Schulz L, Löhr F, Gutfreund N, Finke F, Henrich E, Mezhyrova J, Lehnert R, Pampaloni F, Hummer G, Stelzer EHK, Knapp S, Dötsch V. Gebel J, et al. Among authors: dotsch v. Nat Chem Biol. 2020 Oct;16(10):1078-1086. doi: 10.1038/s41589-020-0600-3. Epub 2020 Jul 27. Nat Chem Biol. 2020. PMID: 32719556
265 results