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Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator.
Dötsch L, Davies C, Hennes E, Schönfeld J, Kumar A, Guita CDCL, Ehrler JHM, Hiesinger K, Thavam S, Janning P, Sievers S, Knapp S, Proschak E, Ziegler S, Waldmann H. Dötsch L, et al. J Med Chem. 2024 Mar 28;67(6):4691-4706. doi: 10.1021/acs.jmedchem.3c02245. Epub 2024 Mar 12. J Med Chem. 2024. PMID: 38470246 Free PMC article.
Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype.
Xue G, Xie J, Hinterndorfer M, Cigler M, Dötsch L, Imrichova H, Lampe P, Cheng X, Adariani SR, Winter GE, Waldmann H. Xue G, et al. Among authors: dotsch l. Nat Commun. 2023 Nov 30;14(1):7908. doi: 10.1038/s41467-023-43657-6. Nat Commun. 2023. PMID: 38036533 Free PMC article.
An analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray in rats.
Iwasaki M, Lefevre A, Althammer F, Clauss Creusot E, Łąpieś O, Petitjean H, Hilfiger L, Kerspern D, Melchior M, Küppers S, Krabichler Q, Patwell R, Kania A, Gruber T, Kirchner MK, Wimmer M, Fröhlich H, Dötsch L, Schimmer J, Herpertz SC, Ditzen B, Schaaf CP, Schönig K, Bartsch D, Gugula A, Trenk A, Blasiak A, Stern JE, Darbon P, Grinevich V, Charlet A. Iwasaki M, et al. Among authors: dotsch l. Nat Commun. 2023 Feb 24;14(1):1066. doi: 10.1038/s41467-023-36641-7. Nat Commun. 2023. PMID: 36828816 Free PMC article.
The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation.
Flegel J, Shaaban S, Jia ZJ, Schulte B, Lian Y, Krzyzanowski A, Metz M, Schneidewind T, Wesseler F, Flegel A, Reich A, Brause A, Xue G, Zhang M, Dötsch L, Stender ID, Hoffmann JE, Scheel R, Janning P, Rastinejad F, Schade D, Strohmann C, Antonchick AP, Sievers S, Moura-Alves P, Ziegler S, Waldmann H. Flegel J, et al. Among authors: dotsch l. J Med Chem. 2022 Dec 22;65(24):16268-16289. doi: 10.1021/acs.jmedchem.2c00956. Epub 2022 Dec 2. J Med Chem. 2022. PMID: 36459434 Free PMC article.
Analysis of the hypothalamic oxytocin system and oxytocin receptor-expressing astrocytes in a mouse model of Prader-Willi syndrome.
Althammer F, Wimmer MC, Krabichler Q, Küppers S, Schimmer J, Fröhlich H, Dötsch L, Gruber T, Wunsch S, Schubert T, Kirchner MK, Stern JE, Charlet A, Grinevich V, Schaaf CP. Althammer F, et al. Among authors: dotsch l. J Neuroendocrinol. 2022 Dec;34(12):e13217. doi: 10.1111/jne.13217. Epub 2022 Dec 1. J Neuroendocrinol. 2022. PMID: 36458331
Identification of a Novel Pseudo-Natural Product Type IV IDO1 Inhibitor Chemotype.
Davies C, Dötsch L, Ciulla MG, Hennes E, Yoshida K, Gasper R, Scheel R, Sievers S, Strohmann C, Kumar K, Ziegler S, Waldmann H. Davies C, et al. Among authors: dotsch l. Angew Chem Int Ed Engl. 2022 Oct 4;61(40):e202209374. doi: 10.1002/anie.202209374. Epub 2022 Aug 29. Angew Chem Int Ed Engl. 2022. PMID: 35959923 Free PMC article.
Cell-Based Identification of New IDO1 Modulator Chemotypes.
Hennes E, Lampe P, Dötsch L, Bruning N, Pulvermacher LM, Sievers S, Ziegler S, Waldmann H. Hennes E, et al. Among authors: dotsch l. Angew Chem Int Ed Engl. 2021 Apr 26;60(18):9869-9874. doi: 10.1002/anie.202016004. Epub 2021 Mar 24. Angew Chem Int Ed Engl. 2021. PMID: 33565680 Free PMC article.
Discovery of Covalent Inhibitors Targeting the Transcriptional Enhanced Associate Domain Central Pocket.
Karatas H, Akbarzadeh M, Adihou H, Hahne G, Pobbati AV, Yihui Ng E, Guéret SM, Sievers S, Pahl A, Metz M, Zinken S, Dötsch L, Nowak C, Thavam S, Friese A, Kang C, Hong W, Waldmann H. Karatas H, et al. Among authors: dotsch l. J Med Chem. 2020 Oct 22;63(20):11972-11989. doi: 10.1021/acs.jmedchem.0c01275. Epub 2020 Oct 1. J Med Chem. 2020. PMID: 32907324 Free PMC article.
11 results