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Modification of the N-terminal sulfonyl residue in 3-amidinophenylalanine-based matriptase inhibitors.
Bioorg Med Chem Lett. 2009 Jan 1;19(1):67-73. doi: 10.1016/j.bmcl.2008.11.019. Epub 2008 Nov 13.
Bioorg Med Chem Lett. 2009.
PMID: 19036586
Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase.
Steinmetzer T, Schweinitz A, Stürzebecher A, Dönnecke D, Uhland K, Schuster O, Steinmetzer P, Müller F, Friedrich R, Than ME, Bode W, Stürzebecher J.
Steinmetzer T, et al. Among authors: donnecke d.
J Med Chem. 2006 Jul 13;49(14):4116-26. doi: 10.1021/jm051272l.
J Med Chem. 2006.
PMID: 16821772
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From selective substrate analogue factor Xa inhibitors to dual inhibitors of thrombin and factor Xa. Part 3.
Dönnecke D, Schweinitz A, Stürzebecher A, Steinmetzer P, Schuster M, Stürzebecher U, Nicklisch S, Stürzebecher J, Steinmetzer T.
Dönnecke D, et al.
Bioorg Med Chem Lett. 2007 Jun 15;17(12):3322-9. doi: 10.1016/j.bmcl.2007.03.105. Epub 2007 Apr 6.
Bioorg Med Chem Lett. 2007.
PMID: 17462889
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Highly potent and selective substrate analogue factor Xa inhibitors containing D-homophenylalanine analogues as P3 residue: part 2.
Stürzebecher A, Dönnecke D, Schweinitz A, Schuster O, Steinmetzer P, Stürzebecher U, Kotthaus J, Clement B, Stürzebecher J, Steinmetzer T.
Stürzebecher A, et al. Among authors: donnecke d.
ChemMedChem. 2007 Jul;2(7):1043-53. doi: 10.1002/cmdc.200700031.
ChemMedChem. 2007.
PMID: 17541992
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Incorporation of neutral C-terminal residues in 3-amidinophenylalanine-derived matriptase inhibitors.
Schweinitz A, Dönnecke D, Ludwig A, Steinmetzer P, Schulze A, Kotthaus J, Wein S, Clement B, Steinmetzer T.
Schweinitz A, et al. Among authors: donnecke d.
Bioorg Med Chem Lett. 2009 Apr 1;19(7):1960-5. doi: 10.1016/j.bmcl.2009.02.047. Epub 2009 Feb 14.
Bioorg Med Chem Lett. 2009.
PMID: 19250826
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