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Novel spirooxindole based benzimidazole scaffold: In vitro, nanoformulation and in vivo studies on anticancer and antimetastatic activity of breast adenocarcinoma.
Barakat A, Alshahrani S, Mohammed Al-Majid A, Saleh Alamary A, Haukka M, Abu-Serie MM, Dömling A, Mazyed EA, Badria FA, El-Senduny FF. Barakat A, et al. Among authors: domling a. Bioorg Chem. 2022 Dec;129:106124. doi: 10.1016/j.bioorg.2022.106124. Epub 2022 Sep 5. Bioorg Chem. 2022. PMID: 36174446
2,30-Bis(10H-indole) heterocycles: New p53/MDM2/MDMX antagonists.
Neochoritis CG, Wang K, Estrada-Ortiz N, Herdtweck E, Kubica K, Twarda A, Zak KM, Holak TA, Dömling A. Neochoritis CG, et al. Among authors: domling a. Bioorg Med Chem Lett. 2015 Dec 15;25(24):5661-6. doi: 10.1016/j.bmcl.2015.11.019. Bioorg Med Chem Lett. 2015. PMID: 26584879 Free PMC article.
Design, Synthesis, Chemical and Biochemical Insights Into Novel Hybrid Spirooxindole-Based p53-MDM2 Inhibitors With Potential Bcl2 Signaling Attenuation.
Aziz YMA, Lotfy G, Said MM, El Ashry ESH, El Tamany ESH, Soliman SM, Abu-Serie MM, Teleb M, Yousuf S, Dömling A, Domingo LR, Barakat A. Aziz YMA, et al. Among authors: domling a. Front Chem. 2021 Dec 14;9:735236. doi: 10.3389/fchem.2021.735236. eCollection 2021. Front Chem. 2021. PMID: 34970530 Free PMC article.
MCR synthesis of a tetracyclic tetrazole scaffold.
Patil P, Khoury K, Herdtweck E, Dömling A. Patil P, et al. Among authors: domling a. Bioorg Med Chem. 2015 Jun 1;23(11):2699-715. doi: 10.1016/j.bmc.2014.12.021. Epub 2014 Dec 20. Bioorg Med Chem. 2015. PMID: 25630499 Free PMC article.
Discovery of chromenes as inhibitors of macrophage migration inhibitory factor.
Kok T, Wapenaar H, Wang K, Neochoritis CG, Zarganes-Tzitzikas T, Proietti G, Eleftheriadis N, Kurpiewska K, Kalinowska-Tłuścik J, Cool RH, Poelarends GJ, Dömling A, Dekker FJ. Kok T, et al. Among authors: domling a. Bioorg Med Chem. 2018 Mar 1;26(5):999-1005. doi: 10.1016/j.bmc.2017.12.032. Epub 2017 Dec 24. Bioorg Med Chem. 2018. PMID: 29428527 Free PMC article.
Synthesis and Enantiomeric Separation of a Novel Spiroketal Derivative: A Potent Human Telomerase Inhibitor with High in Vitro Anticancer Activity.
Fuggetta MP, De Mico A, Cottarelli A, Morelli F, Zonfrillo M, Ulgheri F, Peluso P, Mannu A, Deligia F, Marchetti M, Roviello G, Reyes Romero A, Dömling A, Spanu P. Fuggetta MP, et al. Among authors: domling a. J Med Chem. 2016 Oct 13;59(19):9140-9149. doi: 10.1021/acs.jmedchem.6b01046. Epub 2016 Sep 19. J Med Chem. 2016. PMID: 27592503
Editorial: Isocyanide-Based Multicomponent Reactions.
Rudick JG, Shaabani S, Dömling A. Rudick JG, et al. Among authors: domling a. Front Chem. 2020 Jan 15;7:918. doi: 10.3389/fchem.2019.00918. eCollection 2019. Front Chem. 2020. PMID: 32010668 Free PMC article. No abstract available.
260 results