Díaz JF - Search Results

1

Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy.

Campiani G, Khan T, Ulivieri C, Staiano L, Papulino C, Magnano S, Nathwani S, Ramunno A, Lucena-Agell D, Relitti N, Federico S, Pozzetti L, Carullo G, Casagni A, Brogi S, Vanni F, Galatello P, Ghanim M, McCabe N, Lamponi S, Valoti M, Ibrahim O, O'Sullivan J, Turkington R, Kelly VP, VanWemmel R, Díaz JF, Gemma S, Zisterer D, Altucci L, De Matteis A, Butini S, Benedetti R. Campiani G, et al. Among authors: diaz jf. Eur J Med Chem. 2022 May 5;235:114274. doi: 10.1016/j.ejmech.2022.114274. Epub 2022 Mar 20. Eur J Med Chem. 2022. PMID: 35344902

2

Interaction of epothilone analogs with the paclitaxel binding site: relationship between binding affinity, microtubule stabilization, and cytotoxicity.

Buey RM, Díaz JF, Andreu JM, O'Brate A, Giannakakou P, Nicolaou KC, Sasmal PK, Ritzén A, Namoto K. Buey RM, et al. Among authors: diaz jf. Chem Biol. 2004 Feb;11(2):225-36. doi: 10.1016/j.chembiol.2004.01.014. Chem Biol. 2004. PMID: 15123284

3

Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity.

Buey RM, Barasoain I, Jackson E, Meyer A, Giannakakou P, Paterson I, Mooberry S, Andreu JM, Díaz JF. Buey RM, et al. Among authors: diaz jf. Chem Biol. 2005 Dec;12(12):1269-79. doi: 10.1016/j.chembiol.2005.09.010. Chem Biol. 2005. PMID: 16356844

4

Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules.

Marco JA, García-Pla J, Carda M, Murga J, Falomir E, Trigili C, Notararigo S, Díaz JF, Barasoain I. Marco JA, et al. Among authors: diaz jf. Eur J Med Chem. 2011 May;46(5):1630-7. doi: 10.1016/j.ejmech.2011.02.011. Epub 2011 Feb 22. Eur J Med Chem. 2011. PMID: 21396747

5

Synthesis and biological evaluation as microtubule-active agents of several tetrahydrofuran and spiroacetal derivatives.

Carda M, Murga J, Paños J, Angulo-Pachón CA, García-Pla J, Díaz-Oltra S, Marco JA, Trigili C, Redondo-Horcajo M, Díaz JF, Barasoain I. Carda M, et al. Among authors: diaz jf, diaz oltra s. Curr Med Chem. 2013;20(9):1173-82. doi: 10.2174/0929867311320090006. Curr Med Chem. 2013. PMID: 23317099 Free article.

6

Synthesis and biological evaluation of new oxadiazoline-substituted naphthalenyl acetates as anticancer agents.

Chaaban I, El Khawass el SM, Abd El Razik HA, El Salamouni NS, Redondo-Horcajo M, Barasoain I, Díaz JF, Yli-Kauhaluoma J, Moreira VM. Chaaban I, et al. Among authors: diaz jf. Eur J Med Chem. 2014 Nov 24;87:805-13. doi: 10.1016/j.ejmech.2014.10.015. Epub 2014 Oct 13. Eur J Med Chem. 2014. PMID: 25440882

7

Total Synthesis of Amphidinolide K, a Macrolide That Stabilizes F-Actin.

Sánchez D, Andreou T, Costa AM, Meyer KG, Williams DR, Barasoain I, Díaz JF, Lucena-Agell D, Vilarrasa J. Sánchez D, et al. Among authors: diaz jf. J Org Chem. 2015 Sep 4;80(17):8511-9. doi: 10.1021/acs.joc.5b00966. Epub 2015 Jun 23. J Org Chem. 2015. PMID: 26079383

8

Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressions.

Tang Y, Rodríguez-Salarichs J, Zhao Y, Cai P, Estévez-Gallego J, Balaguer-Pérez F, Redondo Horcajo M, Lucena-Agell D, Barasoain I, Díaz JF, Fang WS. Tang Y, et al. Among authors: diaz jf. Eur J Med Chem. 2017 Sep 8;137:488-503. doi: 10.1016/j.ejmech.2017.06.001. Epub 2017 Jun 3. Eur J Med Chem. 2017. PMID: 28624703

9

Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity.

Bueno O, Tobajas G, Quesada E, Estévez-Gallego J, Noppen S, Camarasa MJ, Díaz JF, Liekens S, Priego EM, Pérez-Pérez MJ. Bueno O, et al. Among authors: diaz jf. Eur J Med Chem. 2018 Mar 25;148:337-348. doi: 10.1016/j.ejmech.2018.02.019. Epub 2018 Feb 10. Eur J Med Chem. 2018. PMID: 29471122

10

A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.

Menchon G, Prota AE, Lucena-Agell D, Bucher P, Jansen R, Irschik H, Müller R, Paterson I, Díaz JF, Altmann KH, Steinmetz MO. Menchon G, et al. Among authors: diaz jf. Nat Commun. 2018 May 29;9(1):2106. doi: 10.1038/s41467-018-04535-8. Nat Commun. 2018. PMID: 29844393 Free PMC article.

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